Transplanting the pulmonary virome: dynamics of transient populations

Community acquired respiratory virus (CARV) infections have been associated with significant acute morbidity and occasional mortality in lung transplant (LTX) recipients. Moreover, there is accumulating evidence that CARV infections may be associated with the development of chronic lung allograft dysfunction (CLAD) (1) for which bronchiolitis obliterans syndrome (BOS) is the most common phenotype although a restrictive phenotype is increasingly recognised (2, 3). CLAD, remains the most important complication limiting the long-term success of lung transplantation and occurs in 50% of recipients within 5 years (4).

Source: The Journal of Heart and Lung Transplantation - June 9, 2018 Category: Transplant Surgery Authors: Alicia B Mitchell, Bassel Mourad, Lucy C. Morgan, Brian G.G. Oliver, Allan R. Glanville Tags: Original Clinical Science Source Type: research