Inhibition of miR-135b by SP-1 promotes hypoxia-induced vascular endothelial cell injury via HIF-1 α.

In conclusion, the SP-1/miR-135b/HIF-1α axis may play a critical role in hypoxia-induced vascular endothelial injury. Our study thus provides novel insights into the role of this transcription factor and miRNAs in the pathogenesis of hypoxia-induced cardiac dysfunctions. PMID: 29883713 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29883713?dopt=Abstract

Source: Experimental Cell Research - June 5, 2018 Category: Cytology Authors: Yang S, Yin J, Hou X Tags: Exp Cell Res Source Type: research