Novel Ultrasonographic Scoring System of Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation

Sinusoidal obstruction syndrome (SOS), also known as hepatic veno-occlusive disease (VOD), is 1 of the life-threatening complications after hematopoietic stem cell transplantation (HSCT) [1]. Typical clinical presentations of SOS/VOD include body weight gain, painful hepatomegaly, ascites, and jaundice [2,3]. The incidence of SOS/VOD after HSCT varies from 5% to 60% [4-10], depending on types of conditioning regimen and cancer treatments before HSCT. SOS/VOD is induced by damage of the hepatic sinusoidal endothelial cells by cytotoxic agents, such as busulfan, cyclophosphamide, gemtuzumab ozogamicin, and inotuzumab ozogamicin [10].

Source: Biology of Blood and Marrow Transplantation - May 24, 2018 Category: Hematology Authors: Mutsumi Nishida, Kaoru Kahata, Eiko Hayase, Akio Shigematsu, Megumi Sato, Yusuke Kudo, Satomi Omotehara, Takahito Iwai, Junichi Sugita, Hitoshi Shibuya, Chikara Shimizu, Takanori Teshima Source Type: research