Targeted inhibition of CD74 attenuates adipose COX-2-MIF-mediated M1 macrophage polarization and retards obesity-related adipose tissue inflammation and insulin resistance

This study suggested that COX-2-mediated MIF secretion through NFB activation from hypertrophic and hypoxic adipocytes as well as M1 macrophages might substantially contribute to the phenotypic switch of AT macrophages through CD74 in obesity. Inhibition of CD74 could attenuate AT inflammation and insulin resistance in the development of HF diet-induced obesity.

Source: Clinical Science - May 17, 2018 Category: Biomedical Science Authors: Chan, P.-C., Wu, T.-N., Chen, Y.-C., Lu, C.-H., Wabitsch, M., Tian, Y.-F., Hsieh, P.-S. Tags: PublishAheadOfPrint Source Type: research