Association of Parkinson ’s disease with industry sectors: a French nationwide incidence study

AbstractIn order to identify working environments at risk for Parkinson ’s disease (PD), we investigated the relation between the importance of industry sectors, used as a surrogate for occupational exposures, and PD incidence in Frenchcantons. The number of incident PD cases (2010 –2014) in 3689cantons of metropolitan France was determined using drug claims from French National Health Insurance databases. The proportions of workers in 38 industry sectors in 2006 were calculated for eachcanton. Associations between the proportions of workers in industry sectors and PD age/sex-standardized incidence ratios were examined using incidence rate ratios (IRR) and 95% confidence intervals (CI) estimated with multilevel negative binomial regressions with a random intercept at thecanton-level and adjusted for smoking, deprivation index, and density of neurologists. We then used two-step semi-Bayes hierarchical regression (HR) to include prior information about exposure to pesticides, metals, and solvents in each industry sector. We identified 112,625 incident cases. PD incidence was higher in areas characterized by high proportions of workers in “Agriculture, forestry and fishing” (IRRHR = 1.042; CI 95% = 1.014–1.070; p-TrendHR = 0.004), “Manufacture of textiles, wearing apparel, leather and related products” (IRRHR = 1.024; CI 95% = 1.005–1.044; p-TrendHR = 0.010), and “Manufacture of basic metals and fabricated metal products, except machiner...
Source: European Journal of Epidemiology - Category: Epidemiology Source Type: research