Laminin-521 Protein Therapy for Glomerular Basement Membrane and Podocyte Abnormalities in a Model of Pierson Syndrome

Conclusions These studies show that GBM composition and function can be altered in vivo via vascular delivery of even very large proteins, which may advance therapeutic options for patients with abnormal GBM composition, whether genetic or acquired.

Source: Journal of the American Society of Nephrology : JASN - April 30, 2018 Category: Urology & Nephrology Authors: Lin, M.-H., Miller, J. B., Kikkawa, Y., Suleiman, H. Y., Tryggvason, K., Hodges, B. L., Miner, J. H. Tags: Basic Research Source Type: research