Tryptophan metabolism contributes to radiation-induced immune checkpoint reactivation in glioblastoma.

CONCLUSION:   Tryptophan metabolism represents a metabolic node in glioblastoma and combining RT with IDO1 inhibition enhances therapeutic response by mitigating RT-induced immune suppression.
PMID: 29691296 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - April 24, 2018 Category: Cancer & Oncology Authors: Kesarwani P, Prabhu A, Kant S, Kumar P, Graham SF, Buelow KL, Wilson GD, Miller CR, Chinnaiyan P Tags: Clin Cancer Res Source Type: research