Metformin ameliorates TGF- β1-induced osteoblastic differentiation of human aortic valve interstitial cells by inhibiting β-catenin signaling.

In conclusion, our results suggest a beneficial effect of metformin based on the prevention of osteoblastic differentiation of human AVICs via inhibition of β-catenin, which indicates the therapeutic potential of metformin for CAVD. PMID: 29679571 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29679571?dopt=Abstract

Source: Biochemical and Biophysical Research communications - April 18, 2018 Category: Biochemistry Authors: Fayuan L, Chong C, Qinyu W, Shi Jiawei, Huadong L, Nianguo D Tags: Biochem Biophys Res Commun Source Type: research