Association Between Depression and Antiretroviral Therapy Use Among People Living with HIV: A Meta-analysis

AbstractDepression is common among people living with HIV (PLHIV). Studies on the relationship between depression and use of antiretroviral therapy (ART) are inconclusive. A meta-analysis was conducted to summarize the relationship between depression and ART use among PLHIV. Ten electronic databases, conference abstracts, and dissertations were searched. A random effects meta-analysis was performed to pool the odds ratio estimates from eligible studies. Subgroup analyses and meta-regression were conducted for moderator analysis. Sensitivity analysis was performed to find influential studies. A funnel plot, the Egger test, and the trim and fill analysis were used to detect publication bias. The pooled sample size was 7375 PLHIV from nine eligible studies. The pooled prevalence of depression was 41% (95% confidence interval [CI] 29 –53%). The pooled ART use rate was 52% (95% CI 37–67%). PLHIV with depression were 14% less likely (pooled odds ratio [OR] = 0.86; 95% CI 0.71–1.05) to use ART than those without depression. Subgroup analyses showed that depression was significantly associated with no ART use (pooled OR 0.84 ; 95% CI 0.71–0.99) among studies with a prospective study design (11 estimates from nine studies). Moderator analyses did not show any statistically significant effects. The publication bias analyses showed small study effects may not exist. Depression was associated with non-use of ART among PLH IV. Studies are needed to explor...
Source: AIDS and Behavior - Category: Infectious Diseases Source Type: research

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Conclusions: We demonstrated that both substance use reduction and abstinence are associated with improvements in depressive symptoms over time.
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - Category: Infectious Diseases Tags: Epidemiology Source Type: research
RESUMO Objetivo: Verificar a associa ção entre o perfil das mulheres que buscaram tratamento especializado para uso de substâncias psicoativas, o tempo de permanência no tratamento e os tipos de substância de uso. Método: Coorte retrospectiva realizada com dados de prontuários de mulheres que buscaram atendimento em um serviço de referência para uso de substâncias psicoativas. Resultados: A amostra final foi de 411 prontuários. Houve associação significativa entre desemprego (p
Source: Revista da Escola de Enfermagem da USP - Category: Nursing Source Type: research
AbstractSocial support is associated with HIV-related health outcomes. However, few studies have explored this longitudinally. We assessed psychometric properties of the Medical Outcomes Study ’s Social Support Survey among women in the Women’s Interagency HIV Study, and explored the longitudinal effects of social support on HIV medication adherence (HIV-positive women) and healthcare utilization (HIV-positive and negative women). The 15 questions loaded into two factors, with Cronbac h’s Alpha >  0.95. Over 3 years, perceived emotional support was associated with optimal medication ...
Source: AIDS and Behavior - Category: Infectious Diseases Source Type: research
Tens of millions of Americans struggle to sleep at night, and many of them turn to sleeping pills for relief. Prescription and over-the-counter sleep aids are especially popular among older adults. A recent study published in the American Journal of Geriatric Psychiatry found that roughly one in three adults ages 65 to 80 use these drugs at least occasionally to fall asleep, and OTC meds like Benadryl and Tylenol PM are the pills of choice for sleepless seniors. Experts say this is concerning for a number of reasons. Studies have linked the regular, long-term use of OTC sleep medicines to some potentially serious side effe...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Baby Boomer Health sleep Source Type: news
AbstractLittle is known about disparities in depression prevalence, treatment, and remission by psychiatric comorbidities and substance use among persons living with HIV (PLWH). We conducted a cross-sectional analysis in a large cohort of PLWH in routine care and analyzed conditional probabilities of having an indication for depression treatment, receiving treatment, receiving indicated treatment adjustments, and achieving remission, stratified by alcohol use, illicit drug use, and panic symptoms. Overall, 34.7% (95% CI 33.9 –35.5%) of participants had an indication for depression treatment and of these, 55.3% (53.8&...
Source: AIDS and Behavior - Category: Infectious Diseases Source Type: research
Suicide is the second leading cause of death for individuals ages 10 to 24 years. More teenagers and young adults die from suicide than from cancer, heart disease, AIDS, birth defects, stroke, pneumonia, influenza, and chronic lung disease, combined. Each day in our nation, there is an average of more than 3470 suicide attempts by young adults attending high school. The main objectives of our literature review are to highlight the importance of recognizing postdischarge period in patients at risk of suicide, critically analyzing the risk and protective factors to formulate an individualized safety plan during transition, a...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Source Type: research
The original version of this article unfortunately contained a mistake in Fig.  1. The figure was incorrectly presented with the results of an additional path model for forgotten antiretroviral therapy (ART) doses that was dropped from the primary analyses.
Source: AIDS and Behavior - Category: Infectious Diseases Source Type: research
AbstractMobile health interventions to promote adherence to antiretroviral therapy among adolescents and young adults living with HIV represent a promising strategy. This pilot study (N  = 37) evaluated the psychosocial impacts of an efficacious adherence intervention, cell phone support (CPS). Participants receiving CPS reported significant decreases in perceived stress, depression, and illicit substance use, and increases in self-efficacy during at least one study assessment period, in comparison to participants receiving usual care. Future research using a larger sample should test for mediators of treatme...
Source: AIDS and Behavior - Category: Infectious Diseases Source Type: research
AbstractThe current prospective observational study evaluated the impact of baseline neurocognitive impairment on future viral load suppression among antiretroviral medication naive persons newly diagnosed with HIV infection. We used the Montreal Cognitive Assessment (MoCA) score less than 26, to identify patients with neurocognitive deficits. Of the 138 patients enrolled; virologic suppression was seen in 61% of the participants, while 72% of the participants had a MoCA score less than 26 at baseline. Variables significantly associated with low MoCA score included higher age (p  
Source: AIDS and Behavior - Category: Infectious Diseases Source Type: research
AbstractDepression and trauma are common among women living with HIV. This is the first study to track the longitudinal course of depression and examine the relationship between depression and trauma over time among women in South Africa. HIV-infected and uninfected women (N  = 148) were assessed at baseline and one year later. Results of a path analysis show the multi-directional and entwined influence of early life stress, other life-threatening traumas across the lifespan, depression and PTSD over the course of HIV. We also observed higher rates of depressive sympt omatology and more persistent cases among inf...
Source: AIDS and Behavior - Category: Infectious Diseases Source Type: research
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