Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis

Alcohol abuse is the most important cause for liver disease worldwide [1]. The most severe form of alcoholic liver disease is alcoholic hepatitis with mortality rates of 20-40% at 1-6 months, and a 90-day mortality rate of up to 75% in severe alcoholic hepatitis [2 –4]. Corticosteroids are the only effective medical therapy but failure in many patients has been reported [2]. There is no cure for patients not responding to medical therapy, except for early liver transplantation that is offered in some centers to a highly selected group of patients [5].

Source: Journal of Hepatology - April 11, 2018 Category: Gastroenterology Authors: Katharina Brandl, Phillipp Hartmann, Lily J. Jih, Donald P. Pizzo, Josepmaria Argemi, Meritxell Ventura-Cots, Sally Coulter, Christopher Liddle, Lei Ling, Stephen J. Rossi, Alex M. DePaoli, Rohit Loomba, Wajahat Z. Mehal, Derrick E. Fouts, Michael R. Luce Source Type: research