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Neuroimaging in amyotrophic lateral sclerosis: current and emerging uses.

Neuroimaging in amyotrophic lateral sclerosis: current and emerging uses. Expert Rev Neurother. 2018 Apr 09;: Authors: Agosta F, Spinelli EG, Filippi M Abstract INTRODUCTION: Several neuroimaging techniques have been used to define in vivo markers of pathological alterations underlying amyotrophic lateral sclerosis (ALS). Growing evidence supports the use of magnetic resonance imaging (MRI) and positron emission tomography (PET) for the non-invasive detection of central nervous system involvement in patients with ALS. Areas covered: A comprehensive overview of structural and functional neuroimaging applications in ALS is provided, focusing on motor and extra-motor involvement in the brain and the spinal cord. Implications for pathogenetic models, patient diagnosis, prognosis, monitoring and the design of clinical trials are discussed. Expert commentary: State-of-the-art neuroimaging techniques provide fundamental instruments for the detection and quantification of upper motor neuron and extra-motor brain involvement in ALS, with relevance for both pathophysiologic investigation and clinical practice. Network-based analysis of structural and functional connectivity alterations and multimodal approaches combining several neuroimaging measures are promising tools for the development of novel diagnostic and prognostic markers to be used at the individual patient level. PMID: 29630421 [PubMed - as supplied by publisher]
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research

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Source: Stem Cell Reports - Category: Stem Cells Source Type: research
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Source: Der Nervenarzt - Category: Neurology Authors: Tags: Nervenarzt Source Type: research
Conditions:   Amyotrophic Lateral Sclerosis;   ALS;   Lou Gehrig Disease;   Lou Gehrig's Disease;   Lou-Gehrigs Disease;   Motor Neuron Disease, Amyotrophic Lateral Sclerosis Intervention:   Drug: BHV-0223 Sponsors:   Biohaven Pharmaceutical Holding Company Ltd.;   Cognitive Research Corporation (CRC) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research
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Source: Neuroscience Letters - Category: Neuroscience Source Type: research
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Source: Neurology - Category: Neurology Authors: Tags: Motor Neuron Diseases: Biomarkers, Outcome Measures, and Therapeutics Source Type: research
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