Therapeutic efficacy of the live-attenuated m. tuberculosis vaccine MTBVAC in a preclinical model of bladder cancer

Intravesical instillation of Bacillus Calmette –Guérin (BCG) has been a first-line therapy for non-muscle invasive bladder cancer for the last four decades. However, this treatment causes serious adverse events in a significant number of patients and a substantial percentage of recurrence episodes. MTBVAC is a live attenuated vaccine derived from a Mycobacterium tuberculosis clinical isolate and is currently under evaluation in clinical trials to replace BCG as a tuberculosis vaccine. Here, we describe for the first time the potential of MTBVAC as a bladder cancer therapy in vitro and in vivo in a preclinical model.
Source: Translational Research - Category: Research Authors: Source Type: research