Wide range of drugs affect growth of gut microbes, study says

It ’s not just antibiotics that affect our microbes – a quarter of drugs designed to act on human cells do so tooA wide range of drugs from cancer therapies to antipsychotics affect the growth of microbes that are found in our gut, researchers say, highlighting that it is not only antibiotics that can have an impact on our internal flora.These microbes, whose genes taken together are known as the gut microbiome, play an important role in our health, including for our immune system and our digestion, and have been linked to a host of diseases such as autoimmune conditions, obesity and mood disorders.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Microbiology Science Drugs Drug resistance Health Source Type: news

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Publication date: February 2019Source: Microbial Pathogenesis, Volume 127Author(s): Pourya Gholizadeh, Majid Mahallei, Ali Pormohammad, Mojtaba Varshochi, Khudaverdi Ganbarov, Elham Zeinalzadeh, Bahman Yousefi, Milad Bastami, Asghar Tanomand, Suhad Saad Mahmood, Mehdi Yousefi, Mohammad Asgharzadeh, Hossein Samadi KafilAbstractRecent studies have been considered to symbiotic interactions of the human gastrointestinal microbiota and human lifestyle-related disorders. The human gastrointestinal microbiota continuously stimulates the immune system against opportunistic and pathogen bacteria from infancy. Changes in gastrointes...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: Available online 29 November 2018Source: Microbial PathogenesisAuthor(s): Pourya Gholizadeh, Majid Mahallei, Ali Pormohammad, Mojtaba Varshochi, Khudaverdi Ganbarov, Elham Zeinalzadeh, Bahman Yousefi, Milad Bastami, Asghar Tanomand, Suhad Saad Mahmood, Mehdi Yousefi, Mohammad Asgharzadeh, Hossein Samadi KafilAbstractRecent studies have been considered to symbiotic interactions of the human gastrointestinal microbiota and human lifestyle-related disorders. The human gastrointestinal microbiota continuously stimulates the immune system against opportunistic and pathogen bacteria from infancy. Changes in gas...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
SummaryWe conducted a hypothesis ‐free cross‐trait analysis for waist‐to‐hip ratio adjusted for body mass index (WHRadjBMI) loci derived through genome ‐wide association studies (GWAS). Summary statistics from published GWAS were used to capture all WHRadjBMI single ‐nucleotide polymorphisms (SNPs), and their proxy SNPs were identified. These SNPs were used to extract cross‐trait associations between WHRadjBMI SNPs and other traits through the NHGRI ‐EBI GWAS Catalog. Pathway analysis was conducted for pleiotropic WHRadjBMI SNPs. We found 160 WHRadjBMI SNPs and 3675 proxy SNPs. Cross ‐trait analysis ident...
Source: Obesity Reviews - Category: Eating Disorders & Weight Management Authors: Tags: OBESITY GENETICS Source Type: research
In conclusion, weight cycling significantly increased life-span relative to remaining with obesity and had a similar benefit to sustained modest weight loss. Support for Oxidized Cholesterol as a Primary Cause of Atherosclerosis https://www.fightaging.org/archives/2018/11/support-for-oxidized-cholesterol-as-a-primary-cause-of-atherosclerosis/ In the paper I'll point out today, the authors provide evidence in support of the concept that it is specifically oxidized cholesterol that is the primary cause of atherosclerosis rather than the condition resulting from too much cholesterol in general. In atheroscl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
When I was a kid, grasshoppers were everywhere. I walked through a field every day to get to school and grasshoppers were everywhere, jumping back and forth across my path, frequently banging off my legs. At night in summer, the backyard was filled with fireflies that we’d chase and capture in jars to watch up close. And there were butterflies of many colors and varieties everywhere, flitting from flower to flower. Today, I don’t see any grasshoppers. In fact, I haven’t seen one in over 40 years. I saw one—just one—firefly this past summer in my backyard. And I can count the number of butterie...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Agribusiness bowel flora Inflammation microbiota prebiotic probiotic wheat belly Source Type: blogs
In this report, we propose that the molecular mechanisms of beneficial actions of CR should be classified and discussed according to whether they operate under rich or insufficient energy resource conditions. Future studies of the molecular mechanisms of the beneficial actions of CR should also consider the extent to which the signals/factors involved contribute to the anti-oxidative, anti-inflammatory, anti-tumor and other CR actions in each tissue or organ, and thereby lead to anti-aging and prolongevity. RNA Interference of ATP Synthase Subunits Slows Aging in Nematodes https://www.fightaging.org/archives/...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In the latter half of the 19th and early 20th century, Dr. John Harvey Kellogg operated a sanitarium in Battle Creek, Michigan, a place where you would stay for a month or two and receive four enemas per day, three meals of thick gruel (a mixture of grains such as wheat, rye, barley, millet or corn), and other treatments to “cure” lumbago, rheumatism, or cancer. Kellogg also advocated a regimen of fresh air, exercise, hydrotherapy and a vegetarian diet that abstained from coffee, tea, alcohol, as well as sex. One day, while preparing a batch of gruel, Dr. Kellogg was called away, only to return hours later to f...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Uncategorized blood sugar grain-free grains low-carb wheat belly Source Type: blogs
Aspirin is once again in the headlines, prompted by New England Journal of Medicine reports suggesting that people aged 70 years and older obtain no benefit and perhaps experience harm in the form of increased bleeding and increased death from cancer on low-dose aspirin. This adds to the decades-long debate on whether aspirin is beneficial as a preventive measure against cardiovascular events such as heart attack in which a blood clot forms on top of inflamed atherosclerotic plaque in the coronary arteries. Unlike many other studies that are observational and therefore virtually useless, these studies are prospective and r...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates aspirin coronary grain-free heart attack heart disease Inflammation platelets Weight Loss wheat belly Source Type: blogs
AbstractThe consequences of atopic dermatitis reach beyond the skin and past childhood. Patients with atopic dermatitis are at risk of developing allergic comorbidities, but less is known about the associations between atopic dermatitis and non-allergic conditions. Understanding these non-allergic comorbidities has the potential to improve patient outcomes and to help mitigate the cost and burdens associated with these conditions. Atopic dermatitis is associated with cutaneous bacterial infections, more severe forms/courses of cutaneous viral infections, and extra-cutaneous infections. Atopic dermatitis is also associated ...
Source: American Journal of Clinical Dermatology - Category: Dermatology Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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