Gastrointestinal hormone can decrease liver fat levels

According to a clinical study, published inThe Lancet, a variant of hormone FGF19 can reduce the liver fat levels of patients with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.Science Daily
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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Conditions:   NAFLD;   Smoking;   Alcohol Consumption;   Bone Mineral Density Intervention:   Sponsor:   Ningbo No. 1 Hospital Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Non-Alcoholic Fatty Liver Disease Interventions:   Behavioral: Conventional diet;   Behavioral: Modified Time-restricted Feeding;   Behavioral: Physical activity;   Behavioral: Restricted consumption of sweetened beverages Sponsor:   The University of Texas Health Science Center, Houston Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   NAFLD;   Smoking;   Alcohol Consumption;   Bone Mineral Density Intervention:   Sponsor:   Ningbo No. 1 Hospital Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Non-Alcoholic Fatty Liver Disease Interventions:   Behavioral: Conventional diet;   Behavioral: Modified Time-restricted Feeding;   Behavioral: Physical activity;   Behavioral: Restricted consumption of sweetened beverages Sponsor:   The University of Texas Health Science Center, Houston Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionIn this review, I will summarize the current findings regarding the role of gut microbiome and metabolites in metabolic disorders to argue whether the current achievements may be translated into clinical practice.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
Research, published inNutrition,Metabolism and Cardiovascular Diseases, suggests that non-alcoholic fatty liver disease increases diabetes risk in non-obese adults.Healio
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
CONCLUSIONS: The presence of comorbidities is already evident in primary school children with obesity. The effect of a lifestyle intervention on these comorbidities is greater in primary compared to secondary school children, stressing the need for early interventions. PMID: 30776292 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
This article is protected by copyright. All rights reserved. PMID: 30773673 [PubMed - as supplied by publisher]
Source: Physiological Research - Category: Physiology Authors: Tags: Clin Exp Pharmacol Physiol Source Type: research
Abstract Mesenteric adipose tissue (MAT) inflammation is associated with non-alcoholic fatty liver disease (NAFLD), and immune cells play pivotal roles in the inflammation of adipose tissue. Here, we investigated the roles of MAT B lymphocytes in NAFLD. Mice fed with high-fat diet (HFD) and normal diet (ND) were killed in time gradients (4, 8 and 12 weeks). Compared with ND-fed mice, intra-hepatic CD45+ CD19+ B lymphocytes increased after 4 weeks (P 
Source: J Cell Mol Med - Category: Molecular Biology Authors: Tags: J Cell Mol Med Source Type: research
Liver cirrhosis is a major cause of morbidity and mortality worldwide. The most common chronic liver diseases in western countries are alcohol-associated liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). Although these diseases have different causes, liver fibrosis develops via shared mechanisms. The liver and intestinal microbiome are linked by the portal vein and have bi-directional interactions. Changes in the intestinal microbiota are believed to contribute to the pathogenesis and progression of liver diseases including ALD, NAFLD, viral hepatitis and cholestatic disorders, based on studies in patients and animal models.
Source: Translational Research - Category: Research Authors: Source Type: research
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