Fertility Clinic Meltdowns Destroyed Frozen Eggs and Embryos. What Happens Now?

Simultaneous refrigeration failures at two fertility clinics in San Francisco and suburban Cleveland have damaged or destroyed potentially thousands of frozen eggs and embryos in the biggest such loss on record in the U.S. The malfunctions have left parents-to-be heartbroken and baffled experts. Here are some questions and answers about the two cases. ___ What happened? In Ohio, University Hospitals Cleveland Medical Center estimates 2,000 eggs and embryos may have been damaged or destroyed when an unexplained storage tank malfunction caused temperatures to rise on March 4. The medical center apologized. On the same day in San Francisco, an embryologist at the Pacific Fertility Clinic noticed the liquid nitrogen level in one tank was very low during a routine check, clinic president Dr. Carl Herbert told ABC. He said the tank was immediately replenished and the embryos were later transferred to a new tank. There’s no known connection between the two episodes, said Dr. Kevin Doody, lab director at the Center for Assisted Reproduction in Texas and past president of the Society for Assisted Reproductive Technology. He said such breakdowns are extremely rare, and two at once is “beyond stunning.” “It’s two black swan events happening in the same day. One of them causes the beehive to buzz. Two? We’re all in shock,” Doody said. Officials have yet to say exactly what went wrong. Barbara Collura, president of the patient advocacy group RESO...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized APH fertility healthytime onetime Source Type: news

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Conclusions: The results of this meta-analysis suggest that SERMs may be effective in the treatment of infertile patients with idiopathic infertility. However, the paucity of data does not allow to draw a definitive conclusion. PMID: 31120775 [PubMed - as supplied by publisher]
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Abstract Considering that myths and misconceptions regarding natural procreation spread rapidly in the era of easy access to information and to social networks, adequate counseling about natural fertility and spontaneous conception should be encouraged in any kind of health assistance. Despite the fact that there is no strong-powered evidence about any of the aspects related to natural fertility, literature on how to increase the chances of a spontaneous pregnancy is available. In the present article, the Brazilian Federation of Gynecology and Obstetrics Associations (FEBRASGO, in the Portuguese acronym) Committee on Endoc...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
This study aimed to evaluate the effect of fenugreek seed aqueous (FSA) extract on serum E2 levels in a rat model of OHSS. Methods: A total of 34 female Sprague Dawley rats, aged 18 days old, weighing 40 to 45 g, were randomly divided into negative control, positive control, and treatment groups. A daily dose of 1500 mg/kg per body weight of FSA extract was administrated orally to rats in the treatment group for 13 days. On day eight of the study, OHSS was induced in both positive control and treated groups by subcutaneous injection of pregnant mare's serum gonadotropin 50 IU for four consecutive days, followed by huma...
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
AbstractPurposeTo investigate whether unexplained infertility at a young age demonstrates manifestations of decreased ovarian reserve.MethodsA total of 100 women were divided into two equally sized groups. The study group comprised women aged ≤ 37 years diagnosed with unexplained infertility, and the control group included age-matched women with either mechanical factor or severe male factor infertility.ResultsBoth groups were comparable in their basic characteristics. Overall, women with unexplained infertility presented with inferior ovarian reserve results set against women of the control group. The numbe...
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
The first case is a 36-years-old nulliparous patient was referred for dysmenorrhea, deep dyspareunia and infertility. Physical examination revealed a tender retrocervical nodule that was confirmed by transvaginal ultrasound with bowel preparation. Imaging also showed a 3 cm rectosigmoid nodule compromising the muscularis and the submucosa and an appendiceal nodule measuring 1.2  × 0.7 × 0.6 cm. Patient opted for expectant management of endometriosis, underwent in-vitro fertilization (IVF) treatment for infertility and had a successful pregnancy and delivery.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: IMAGES IN Gynecological Surgery Source Type: research
ConclusionsThe results of this study offer some support for evaluating the effect of pretreatment with LNG-IUS in women with adenomyosis in future randomized controlled trials.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Publication date: Available online 15 May 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Maja Šikic Pogacar, Veljko Vlaisavljević, Eva Turk, Dušanka Mičetić-TurkAbstractObjectiveCeliac disease is associated with higher risk of infertility, recurrent abortions, and adverse outcomes in pregnancy and in puerperium. The aim of the study was to analyse the association between celiac disease and reproductive disorders in the group of celiac patients and compare these to healthy controls.MethodsA retrospective case-control matched study. The association between celia...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Publication date: Available online 15 May 2019Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Hanna Hürter, Shane Vontelin van Breda, Lenka Vokalova, Marlene Brandl, Marc Baumann, Irene Hösli, Evelin Annegret Huhn, Christian De Geyter, Simona W. Rossi, Olav LapaireAbstractAlthough an increased risk of pre-eclampsia in pregnancies conceived after infertility treatment has been reported, it remains unknown whether preconceptional minimalisation of known risk factors would help in preventing pre-eclamsia. Obesity and preconceptional blood pressure are discussed as major risks for...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
To evaluate whether maternal chronic hepatitis B virus (HBV) infection affects pregnancy outcomes in infertile patients undergoing their first in  vitro fertilization (IVF) treatment.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Original article Source Type: research
ConclusionsMicrofluidic chip method may be recommended in patients with recurrent unsuccessful in vitro trials. The sperm DNA fragmentation test prior to the treatment will be helpful in selecting the appropriate sperm-washing method.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
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