Effects of low concentrations of ibuprofen on freshwater fish Rhamdia quelen

This study evaluated the effects of ibuprofen in environmental concentrations (0, 0.1, 1 and 10 μg/L) on the freshwaterspecies Rhamdia quelen exposed for 14 days. In the posterior kidney, ibuprofen increased glutathione-S-transferase activity in all groups exposed. Furthermore, increased glutathione peroxidase activity and the levels of reduced glutathione in the group exposed to 10 μg/L. Ibuprofen decreased the carbonic anhydrase activity in the posterior kidney in all exposed groups, and increased the activity in the gills in group exposed to 0.1 μg/L. The levels of plasma magnesium increased in groups exposed to 0.1 and 1μg/L. In the blood, ibuprofen decreased the white blood cell count in groups exposed to 0.1 e 1.0 μg/L. Therefore, these results indicated that ibuprofen caused nephrotoxicity and demonstrated immunosuppressive effect in Rhamdia quelen.
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research