Characterization of metastatic urothelial carcinoma via comprehensive genomic profiling of circulating tumor DNA

CONCLUSIONSAmong patients with mUC for whom no tumor tissue was available, cfDNA NGS was able to identify a similar profile of GAs for biomarker‐driven clinical trials compared with tumor tissue. Despite the more aggressive clinical course, cases of mUTUC demonstrated a circulating tumor DNA genomic landscape that was similar to that of mLTUC. Cancer 2018. © 2018 American Cancer Society.

Source: Cancer - March 8, 2018 Category: Cancer & Oncology Authors: Neeraj Agarwal, Sumanta K. Pal, Andrew W. Hahn, Roberto H. Nussenzveig, Gregory R. Pond, Sumati V. Gupta, Jue Wang, Mehmet A. Bilen, Gurudatta Naik, Pooja Ghatalia, Christopher J. Hoimes, Dharmesh Gopalakrishnan, Pedro C. Barata, Alexandra Drakaki, Bishoy Tags: Original Article Source Type: research