Relevance of CYP3A4*20, UGT1A1*37 and UGT1A1*28 variants in irinotecan ‐induced severe toxicity

ConclusionsWe confirm that UGT1A1*37 and UGT1A1*28 are associated with severe toxicity and suggest that the CYP3A4*20 allele does not play a role in irinotecan‐induced toxicity.

Source: British Journal of Clinical Pharmacology - March 1, 2018 Category: Drugs & Pharmacology Authors: P. Riera, J. Salazar, A. Virgili, M. Tobe ña, A. Sebio, P. Gallano, A. Barnadas, D. Páez Tags: SHORT REPORT Source Type: research