Alterations in cholesterol metabolism –related genes in sporadic Alzheimer's disease

Genome-wide association studies have identified several cholesterol metabolism –related genes as top risk factors for late-onset Alzheimer's disease (LOAD). We hypothesized that specific genetic variants could act as disease-modifying factors by altering the expression of those genes. Targeted association studies were conducted with available genomic, transcriptomic, proteom ic, and histopathological data from 3 independent cohorts: the Alzheimer's Disease Neuroimaging Initiative (ADNI), the Quebec Founder Population (QFP), and the United Kingdom Brain Expression Consortium (UKBEC).

Source: Neurobiology of Aging - February 8, 2018 Category: Neuroscience Authors: Cynthia Picard, C édric Julien, Josée Frappier, Justin Miron, Louise Théroux, Doris Dea, United Kingdom Brain Expression Consortium and for the Alzheimer's Disease Neuroimaging Initiative, John C.S. Breitner, Judes Poirier Source Type: research