Prescribed Dose of Opioids and Overdose: A Systematic Review and Meta-Analysis of Unintentional Prescription Opioid Overdose

ConclusionsA significantly increased risk of inadvertent prescription opioid overdose was found with 20 –50 MME/day, with fatality more likely with opioid doses above 50 MME/day, although extensive heterogeneity was found with the dose comparisons. Clinicians should inform patients of this risk and monitor them closely.Protocol RegistrationThis protocol was registered with PROSPERO 2017: CRD42017058426.
Source: CNS Drugs - Category: Neurology Source Type: research