N-Terminal Pro B-Type Natriuretic Peptide Is Inversely Correlated With Low Density Lipoprotein Cholesterol In The Very Elderly

Laboratory studies on human adipose tissue and differentiated adipocytes indicate that natriuretic peptides (NPs) affect lipid metabolism and plasma cholesterol. Few previous clinical studies in non-elderly populations found associations between NPs in the physiological range and cholesterol. Aim: evaluate the association between NT-proBNP and lipid profile in very elderly hospitalized patients characterized by a wide range of NT-proBNP levels.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research

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ConclusionDietary application of nanoceria combined with probiotic strainsL. casei IMV B-7280,B. animalis VKB, andB. animals VKL has significantly reduced both free and bound cholesterol levels in serum. Simultaneous administration of probiotics and cerium nanoparticles as a prebiotic, in various combinations, significantly enhanced positive individual effects of them on the gut microbiota spectrum. The presented results provide novel insights into mechanisms behind nutritional supplements and open new perspectives for application of probiotics combined with substances demonstrating prebiotic qualities benefiting, therefor...
Source: EPMA Journal - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 4 February 2019Source: Aquatic ToxicologyAuthor(s): Paolo Cocci, Gilberto Mosconi, Francesco Alessandro PalermoAbstractMetabolism disrupting chemicals (MDCs) belong to the group of endocrine-disrupting chemicals (EDCs) and are known to affect endocrine and metabolic functions of liver. There is growing evidence that MDCs may also act modulating the expression levels of micro ribonucleic acids (miRNAs) and thus affecting post-transcriptional expression of hundreds of target genes. Herein, we used a gilthead sea bream in vitro hepatocyte model for analyzing the effects of an exposure to pht...
Source: Aquatic Toxicology - Category: Toxicology Source Type: research
Abstract Metabolism disrupting chemicals (MDCs) belong to the group of endocrine-disrupting chemicals (EDCs) and are known to affect endocrine and metabolic functions of liver. There is growing evidence that MDCs may also act modulating the expression levels of micro ribonucleic acids (miRNAs) and thus affecting post-transcriptional expression of hundreds of target genes. Herein, we used a gilthead sea bream in vitro hepatocyte model for analyzing the effects of an exposure to phthalates (i.e. DiDP) or flame retardants (i.e.TMCP) on the expression levels of three miRNAs (i.e. MiR133, MiR29 and MiR199a) selected on...
Source: Aquatic Toxicology - Category: Toxicology Authors: Tags: Aquat Toxicol Source Type: research
Conditions:   Valley Fever;   Coccidioidomycosis Intervention:   Other: Cholesterol-containing moisturizers Sponsor:   University of Arizona Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion Our real-life clinical study supports the hypothesis that NPs play a role on cholesterol metabolism, given the association found between LDLc and NT-proBNP even in very elderly patients where NT-proBNP values are often in the pathological range.
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Laboratory studies on human adipose tissue and differentiated adipocytes indicate that natriuretic peptides (NPs) affect lipid metabolism and plasma cholesterol. Few previous clinical studies in non-elderly populations found associations between NPs in the physiological range and cholesterol. Aim: evaluate the association between NT-proBNP and lipid profile in very elderly hospitalized patients characterized by a wide range of NT-proBNP levels.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research
Cardiovascular diseases are mainly related to hypertension and dyslipidemia and increase with aging because of the larger time span for these risk factors to damage arterial blood vessels. The impact of cardiovascular drug therapy on outcomes in the very elderly hospitalized is still not well established. The aim of our study was to evaluate the associations between cardiovascular therapy and in-hospital mortality in very elderly hypertensives.
Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Tags: Original Study Source Type: research
Aim: Human adipose tissue and adipocyte studies indicate that increased natriuretic peptides (NP) activity correlates with higher LDL receptor expression and lower plasma cholesterol levels. Very elderly patients have often high NP levels for concomitant heart failure that can be diagnose when NTproBNP>1800 pg/ml. We evaluated associations between NP levels and lipid profile in a very elderly population.
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
Publication date: Available online 11 April 2015 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Matteo Mozzicafreddo , Massimiliano Cuccioloni , Laura Bonfili , Valentina Cecarini , Francesco Alessandro Palermo , Paolo Cocci , Gilberto Mosconi , Aida Capone , Irene Ricci , Anna Maria Eleuteri , Mauro Angeletti Liver X receptor is a ligand-activated transcription factor, which is mainly involved in cholesterol homeostasis, bile acid and triglycerides metabolism, and, as recently discovered, in the glucose metabolism by direct regulation of liver glucokinase. Its modulation by exogenous factors...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
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