Psychiatric illnesses share similar gene activity

At least three neuropsychiatric disorders -- autism, schizophrenia and bipolar disorder -- appear to share similar patterns of gene activity, a new study suggests.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news

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Last year, Molecular Brain became the first BMC journal to introduce Micro Reports, an innovative way to quickly share research which would otherwise go unpublished as a full research paper. Micro Reports are short research summaries of up to 1200 words, ideal for publishing negative results, reproduced studies, smaller data sets which are still important but would not warrant a full research article, and brand new findings which should enter the public domain as soon as possible. Since the launch of this new article type, the journal has received 58 Micro Report submissions, with 24 publications to date. We’ve highl...
Source: BioMed Central Blog - Category: General Medicine Authors: Tags: Biology Open Access Publishing Molecular Brain neuroscience SfN19 Source Type: blogs
Abstract Epidemiological studies demonstrate an association between asthma and mental health disorders, although little is known about the shared genetics and causality of this association. Thus, we aim to investigate shared genetic and the causal link between asthma and mental health disorders.We conducted a large-scale genome-wide cross-trait association study to investigate genetic overlap between asthma from UK Biobank and 8 mental health disorders from Psychiatric Genomics Consortium, including: attention deficit hyperactivity disorder (ADHD), anxiety disorder (ANX), autism spectrum disorder, bipolar disorder...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Eur Respir J Source Type: research
Abstract Chromosome conformation capture methods have revealed the dynamics of genome architecture which is spatially organized into topologically associated domains, with gene regulation mediated by enhancer-promoter pairs in chromatin space. New evidence shows that endogenous hormones and several xenobiotics act within circumscribed topological domains of the spatial genome, impacting subsets of the chromatin contacts of enhancer-gene promoter pairs in cis and trans Results from the National Institutes of Health-funded PsychENCODE project and the study of chromatin remodeling complexes have converged to provide ...
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Tags: Pharmacol Rev Source Type: research
 Chrisa Hickey’s journey into mental health advocacy started when her son, Tim, was diagnosed with very early onset schizophrenia after being admitted to a psychiatric hospital for the first time at the age of 11.  He had been showing symptoms for years and had received a half dozen different diagnoses. His family was desperately looking for answers. Tim’s illness took a toll on the entire family, which was only exacerbated by the lack of information and resources available to them.  In America, fewer than 100 children per year are diagnosed with very early onset schizophrenia. Chrisa had to find ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Bipolar Children and Teens Depression Family General Mental Health and Wellness Parenting Podcast Psychiatry Psychology Schizophrenia The Psych Central Show Source Type: blogs
Everyone complains about work. Having to go to work every day, working too much, not getting paid enough- working can be challenging for so many reasons. Today’s episode focuses on working while having schizophrenia.  Host Rachel Star Withers, a diagnosed schizophrenic, and co-host Gabe Howard share antidotes from their own work lives and speak with fellow schizophrenic Michelle Hammer. Michelle, an award-winning graphic designer and entrepreneur, discusses her struggles working full time and transitioning to working for herself. Cheryl Wallace the Vice President of Programs at Rose Hill Center, a psychiatric tr...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: A Bipolar, A Schizophrenic, and a Podcast Inside Schizophrenia Mental Health and Wellness Self-Help Employment life with schizophrenia Living With Schizophrenia mental illness at work Psychology working working and schizophrenia Source Type: blogs
We describe the fundamental principles and basic techniques used in microbiome-gut-brain axis research in an accessible way for a clinician audience. We summarize the current evidence in relation to microbiome-based strategies for various psychiatric disorders and provide some practical advice that can be given to patients seeking to try a probiotic for mental health benefit. PMID: 31530002 [PubMed - as supplied by publisher]
Source: Canadian Journal of Psychiatry - Category: Psychiatry Authors: Tags: Can J Psychiatry Source Type: research
Copy number variation refers to the fact that the number of copies of a particular gene in the genotype may vary among individuals. Rare copy number variants (CNVs) have been implicated in neuropsychiatric disorders, such as schizophrenia, bipolar disorder, and autism spectrum disorder. In this issue of Biological Psychiatry, Bodkin et  al. (1) identified several CNVs spanning 9p24.1 in a proband and his mother whose DSM-IV diagnoses were schizoaffective disorder and bipolar disorder with psychotic features, respectively.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
Neuropsychiatric disorders, such as depression, bipolar, schizophrenia, obsessive-compulsive disorder, and neuropsychiatric disorders such as autism spectrum disorder, are associated with significant illness burden. Accumulating evidence supports an association between neuropsychiatric illnesses and inflammatory processes. Consequently, potent anti-inflammatory agents, such as the cyclooxygenase-2 inhibitors, represent a novel avenue to prevention and treatment of neuropsychiatric illness. In this paper, we first review the role of inflammation in psychiatric pathophysiology including inflammatory cytokines’ influenc...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
AbstractBackgroundAverage paternal age in the United States has increased substantially in the last few decades. Children of advanced age fathers have a higher incidence of early onset cancer and neuropsychiatric disease.ObjectivesTo quantify the number of population adjusted cases of early ‐onset cancer and neuropsychiatric disease in children attributable to increasing paternal age in the United States.MethodsPaternal age in the United States from 1972 to 2015 was collected using the National Vital Statistics System (NVSS). Population attributable fraction and paternal age ‐specific cumulative incidence rates of seve...
Source: Andrology - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
Publication date: Available online 22 August 2019Source: The Lancet PsychiatryAuthor(s): Meng-Chuan Lai, Caroline Kassee, Richard Besney, Sarah Bonato, Laura Hull, William Mandy, Peter Szatmari, Stephanie H AmeisSummaryBackgroundCo-occurring mental health or psychiatric conditions are common in autism, impairing quality of life. Reported prevalences of co-occurring mental health or psychiatric conditions in people with autism range widely. Improved prevalence estimates and identification of moderators are needed to enhance recognition and care, and to guide future research.MethodsIn this systematic review and meta-analysis...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
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