Remote limb ischemic postconditioning promotes motor function recovery in a rat model of ischemic stroke via the up-regulation of endogenous tissue kallikrein.

CONCLUSION: Our study demonstrates RIPostC treatment as an effective rehabilitation therapy to provide motor function recovery and alleviate brain impairment in a rat model of acute cerebral ischemia. We also for the first time provide evidence showing that the up-regulation of endogenous TK from remote conditioning regions underlies the observed effects of RIPostC. PMID: 29399973 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29399973?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - February 4, 2018 Category: Neuroscience Authors: Liang D, He XB, Wang Z, Li C, Gao BY, Wu JF, Bai YL Tags: CNS Neurosci Ther Source Type: research