Post-marketing surveillance study of the safety and efficacy of nalfurafine hydrochloride (Remitch ® capsules 2.5 μg) in 3,762 hemodialysis patients with intractable pruritus.

Post-marketing surveillance study of the safety and efficacy of nalfurafine hydrochloride (Remitch® capsules 2.5 μg) in 3,762 hemodialysis patients with intractable pruritus. Int J Nephrol Renovasc Dis. 2018;11:9-24 Authors: Kozono H, Yoshitani H, Nakano R Abstract Background: Intractable pruritus in hemodialysis patients can significantly decrease their quality of life and is also associated with poor vital prognosis. Although combined multiple causes of intractable pruritus in these patients have been identified, no existing treatments are proven to be sufficiently effective. We conducted a post-marketing surveillance to follow-up and assess the safety and efficacy of nalfurafine, a selective κ-opioid receptor agonist, for the treatment of intractable pruritus in patients undergoing hemodialysis. Patients and methods: Hemodialysis patients with intractable pruritus from institutions in Japan who received oral nalfurafine hydrochloride between January 2010 and December 2013 were enrolled in the surveillance. Surveillance was completed in July 2015. Safety data during 1 year after nalfurafine treatment onset, and efficacy data of nalfurafine evaluating the first 12-week treatment period and the following period until 1 year after the initial dose of nalfurafine (using global assessment of the itch improvement by the physician, Visual Analog Scale, and the Shiratori's severity scores) were collected and analyzed. Results: In total, 3,7...
Source: International Journal of Nephrology and Renovascular Disease - Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

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Publication date: March 2020Source: Epilepsy &Behavior, Volume 104, Part AAuthor(s): Diana Paardekooper, Zoe Thayer, Laurie Miller, Armin Nikpour, Michael B GascoigneAbstractSleep difficulties are commonly reported by patients with epilepsy and can have a detrimental impact on overall quality of life. The purpose of this pilot study was to assess the efficacy of a psychotherapeutic approach, namely Cognitive Behavioral Therapy for Insomnia (CBT-I), in improving sleep quality in patients with epilepsy. Twenty outpatients with epilepsy who reported poor sleep quality were randomized to either a control or CBT-I treatment...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 24 January 2020Source: Canadian Journal of CardiologyAuthor(s): Toshiki Kuno, Hisato Takagi, Tomo Ando, Hiroki Ueyama, Fujisaki Tomohiro, Masaki Kodaira, Yohei Numasawa, Alexandros Briasoulis, Kentaro HayashidaAbstractBackgroundTranscatheter aortic valve implantation (TAVI) has become the main treatment for symptomatic severe aortic stenosis but patients on dialysis have been excluded from major randomized controlled trials. Our aim was to compare mortality and procedure-related complications after TAVI in patients with end-stage renal disease (ESRD) on dialysis versus those without.Metho...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
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Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
This study verified that MafF acted as a tumorsuppressor in HCC and revealed the upstream regulation mechanism of MafF, which provided anew perspective for potential therapeutic targets of HCC. PMID: 31969212 [PubMed - as supplied by publisher]
Source: Oncology Research - Category: Cancer & Oncology Tags: Oncol Res Source Type: research
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Antipsychotics are widely used off-label in clinical practice, especially within palliative care. Palliative care and hospice clinicians often prescribe antipsychotics for off-label uses such as delirium, nausea, agitation, and insomnia even though controversial evidence exists for their use for these indications, given antipsychotics daunting side effect profile. A review of literature of antipsychotics for off-label uses will be completed and supplemented by expert opinion in a debate format as there are known risks and benefits to antipsychotic use, even when used more liberally in the palliative care world.
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
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Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
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