Researchers find link between breast cancer and two gene mutations

(Springer) Individuals with Lynch syndrome, a genetic condition that has long been known to carry dramatically increased risk of colorectal cancer and uterine cancer, now also have an increased risk of breast cancer. This is the conclusion of a study in the journal Genetics in Medicine which is published by Springer Nature.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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A. Kumarasamy and G. A. Kurian*
Source: Indian Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Source Type: research
P. S. Kumar* S. Durgadevi, A. Saravanan and S. Uma
Source: Indian Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Source Type: research
T. H. Tran, Hanh Thuy Nguyen, C. S. Yong, D. H. Truong* and J. O. Kim*
Source: Indian Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Source Type: research
A. Shirkavad, Zahra N. Borojeni and S. E. Aleyasin*
Source: Indian Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Source Type: research
AbstractBackgrounds: The role of long non-coding RNAs (lncRNA) in gastric cancer (GC) has been highlighted in studies conducted over the past decade. However, the potential clinical value and the mechanisms of action of RP11 –6O2.4 in GC have not been thoroughly elucidated to date. The specific aim of the present study was to assess RP11–6O2.4 and to explore its role in human GC.Methods: Quantitative real-time polymerase chain reaction (qPCR) was performed to analyze the expression levels of RP11-6O2.4 in GC tissues, paired adjacent noncancerous tissues (ANTs) and GC cell lines. In addition, the correlation bet...
Source: Molecular and Cellular Toxicology - Category: Cytology Source Type: research
Conclusion: These results provide insights into the importance of chemical modification of unstable genetic therapeutics for HCC treatment. Conjugation of PEGylated GEP siRNA with ARP may be a potential HCC therapeutic agent.
Source: Molecular and Cellular Toxicology - Category: Cytology Source Type: research
AbstractPurpose of review: Exosomes are nano-sized extracellular vesicles ranging from 30 –150 nm in diameter. Exosomes interact with nearby or distantly localized recipient cells by involving ligand/receptor binding at the surface of recipient cells or fusion with plasma membrane of recipient cells. A number of recent literatures support the role of integrins in mediating metastatic p rocess of cancer cell derived exosomes. While exosomes need to dock on the surface of recipient cells to transmit signals or transfer their contents, the process of docking and uptake of exosomes by recipient cells is poorly understood...
Source: Molecular and Cellular Toxicology - Category: Cytology Source Type: research
Conclusion: Ce6-mediated PDT might be used as a potent therapeutics for AD via restoring Th1/Th2 balance and reducing over expressed immune cells.
Source: Molecular and Cellular Toxicology - Category: Cytology Source Type: research
Ovarian cancer is always the bridesmaid, never the bride. At weddings, there’s a reason we focus on the bride. It’s her big event. She’s the center of attention, and rightly so. But sometimes, the bridesmaid’s speech has more to tell us — and we should listen. We hear a lot about breast cancer. It affects a quarter of a million women and is fatal 15 to 20 percent of the time. Breast cancer is a serious and important disease that merits the time, money, and resources we spend on funding and public awareness each year. But what do you know about ovarian cancer, a disease with a fatality rate of ...
Source: Disruptive Women in Health Care - Category: Consumer Health News Authors: Tags: Access Cancer Women Veterans Source Type: blogs
DISCUSSION: Improving medical practice based on diagnostic algorithms addresses the four risk groups, by improving information system reporting and record keeping. Improving addressability cases by increasing the health education of the population will increase the rate of diagnosis of endometrial cancer in the early stages of the disease. ABBREVIATIONS: ACOG = American Society of Obstetricians and Gynecologists, ASCCP = American Society for Colposcopy and Cervical Pathology, PATT = Partial Activated Thromboplastin Time, BRCA = Breast Cancer Gene, CT = Computerized Tomography, IFGO = International Federation of Gynecol...
Source: Journal of Medicine and Life - Category: Journals (General) Tags: J Med Life Source Type: research
More News: Breast Cancer | Cancer | Cancer & Oncology | Cancer of the Uterus | Colorectal Cancer | Genetics | HNPCC | Lynch Syndrome | Study