Candidate Gene Analysis in the S ão Paulo Epidemiologic Sleep Study (EPISONO) Shows an Association of Variant in PDE4D and Sleepiness
This study explored the associations between subjective sleepiness and single nucleotide polymorphisms (SNPs) in candidate genes within oxidative stress, inflammatory and neuronal pathways, which may contribute to sleepiness and downstream cardiovascular disease risk: Cytochrome B-245, Alpha Polypeptide (CYBA), Cytochrome B-245, Beta Polypeptide (CYBB), Neutrophil Cytosolic Factor (NCF2), Tumor Necrosis Factor-Alpha (TNFA) and Phosphodiesterase 4D (PDE4D).
Source: Sleep Medicine - Category: Sleep Medicine Authors: Victoria M. Pak, Diego R. Mazzotti, Brendan T. Keenan, Camila Hirotsu, Philip Gehrman, Lia Bittencourt, Allan I. Pack, Sergio Tufik Tags: Original Article Source Type: research
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