Can vitamins and dietary supplements benefit patients with mitochondrial disease?

(Children's Hospital of Philadelphia) Defects in mitochondria, the tiny structures that power cells by functioning as biological batteries, cause an array of complex disorders that can affect any and all organs and systems. In the absence of validated, effective drug treatments, patients with mitochondrial disease often take a variety of vitamins and supplements, substances that are largely unstandardized, unregulated, and unproven. Experts in the field are calling for systematic studies to evaluate nutritional interventions.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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This article is part of a Special Issue entitled: Genetic and epigenetic regulation of aging and longevity edited by Jun Ren &Megan Yingmei Zhang.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Activation of protein kinase C-α/heme oxygenase-1 signaling pathway improves mitochondrial dynamics in lipopolysaccharide-activated NR8383 cells. Exp Ther Med. 2018 Aug;16(2):1529-1537 Authors: Li X, Zhang Y, Yu J, Mu R, Wu L, Shi J, Gong L, Liu D Abstract Mitochondrial function and morphology are dynamically regulated by fusion and fission. Heme oxygenase-1 (HO-1), which may be upregulated by protein kinase C-α (PKC-α), improves mitochondrial dynamics by controlling the balance between fusion and fission in vivo and in vitro. However, whether the PKC-α/HO-1 signaling pathway is...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
All patients with a suspected mitochondrial disease should be seen by a mitochondrial medicine expert. But what can the primary care clinician do while waiting for that to happen?CHOP Expert Commentary
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Pediatrics Commentary Source Type: news
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Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
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Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
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Source: Metabolic Brain Disease - Category: Neurology Source Type: research
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Source: Current Hypertension Reports - Category: Primary Care Source Type: research
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Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Molecular Biophysics Source Type: research
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Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
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