Brain metastases: epidemiology.

Brain metastases: epidemiology. Handb Clin Neurol. 2018;149:27-42 Authors: Ostrom QT, Wright CH, Barnholtz-Sloan JS Abstract Brain metastases (BM) are the most commonly diagnosed type of central nervous system tumor in the United States. Estimates of the frequency of BM vary significantly, as there is no nationwide reporting system for metastases. BM may be the first sign of a previously undiagnosed cancer, or occur years or decades after the primary cancer was diagnosed. Incidence of BM varies significantly by primary cancer site. Lung, breast, and melanoma continue to be the leading cause of BM. These tumors are increasingly more common as new therapeutics, advanced imaging, and improved screening have led to lengthened survival after primary diagnosis for cancer patients. BM are difficult to treat, and for most individuals the diagnosis of BM generally portends a poor prognosis. PMID: 29307358 [PubMed - in process]
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Handb Clin Neurol Source Type: research

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Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Cancer healthytime Source Type: news
Conclusions: Our findings show that the control groups of tumor-bearing mice, which underwent either standard surgery under white light only or under the fluorescence guidance of the commercially-available imaging agents ProSense® 680 or 5-aminolevulinic acid (5-ALA), survived for less time and suffered from tumor recurrence earlier than the group that underwent image-guided surgery (IGS) using our Turn-ON probes. Our "smart" polymeric probes can potentially assist surgeons' decision in real-time during surgery regarding the tumor margins needed to be removed, leading to improved patient outcome.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Conclusions: PET imaging with radiolabeled amino acids has been shown be effective for brain tumor imaging, providing high contrast between tumor and normal brain parenchyma. The synthetic leucine amino acid analogue, fluciclovine has been recently FDA approved for evaluation of biochemical recurrent prostate cancer. Recent studies have been published demonstrating the utility of fluciclovine for glioma evaluation. Our findings suggest that fluciclovine can similarly be used for evaluation of new or recurrent brain metastasis in patients who previously have undergone brain radiotherapy where MRI is often limited due to bac...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Preclinical Probes for Oncology Posters Source Type: research
The California attorney general has filed an emergency request with the state court of appeals to reverse a lower court ruling to invalidate the End of Life Option Act. The End of Life Option Act remains in effect until further notice. Similar to laws in Washington, D.C. and six other states, the California law gives mentally capable, terminally ill adults with six months or less to live to the option to request prescription medication they can decide to take to end unbearable suffering and die peacefully in their sleep. Last Tuesday, Riverside County Superior Court Judge Daniel Ottolia invalidated the law ...
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: Health Care syndicated Source Type: blogs
A California judge granted a motion by opponents of the California End of Life Option Act to overturn the law because he said the legislature violated the state constitution by passing it during a special session limited to health care issues. (HT: C&C) Riverside County Superior Court Judge Daniel A. Ottolia gave the state attorney general five days to file an emergency appeal of the ruling in the case, Ahn vs. Hestrin — Case RIC1607135, before it will take effect. Unless the appeals court suspends the ruling, it will prevent mentally capable, terminally ill adults with six months or les...
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: Health Care syndicated Source Type: blogs
Conclusion: The incidence of BM from lung and breast cancer was similar to that seen in the Western studies. However, BM from colorectal cancer and melanoma show a higher and lower incidence, respectively, in comparison with the Western literature.
Source: Neurology India - Category: Neurology Authors: Source Type: research
Brain metastases (BM) are the most common intracranial neoplastic disease in adults, with an incidence of 9 –17% among all brain tumors (Nayak et al., 2012). They are usually caused by lung cancer (either non-small cell (NSCLC) and small cell (SCLC) histologies), breast cancer, melanoma and renal cell carcinoma, with a raising incidence related to the improvements in diagnostic and treatment approaches (Berghoff et al., 2014). However, prognosis remains poor, with a median overall survival (OS) ranging from 3 to 27 months (Brastianos et al., 2013), rendering BM still an unmet medical need.
Source: Critical Reviews in Oncology Hematology - Category: Cancer & Oncology Authors: Source Type: research
Brain metastases (BM) are the most common intracranial neoplastic disease in adults, with an incidence of 9-17% among all brain tumors (Nayak et al., 2012). They are usually caused by lung cancer (either non-small cell (NSCLC) and small cell (SCLC) histologies), breast cancer, melanoma and renal cell carcinoma, with a raising incidence related to the improvements in diagnostic and treatment approaches (Berghoff et al., 2014). However, prognosis remains poor, with a median overall survival (OS) ranging from 3 to 27 months (Brastianos et al., 2013), rendering BM still an unmet medical need.
Source: Critical Reviews in Oncology Hematology - Category: Cancer & Oncology Authors: Source Type: research
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Source: Central European Journal of Public Health - Category: International Medicine & Public Health Tags: Cent Eur J Public Health Source Type: research
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