The association of adult vaccination with the risk of cerebrovascular ischemia: A systematic review and meta-analysis

There is mounting evidence supporting infection as an independent risk factor for ischemic stroke (IS), while preliminary data indicate that vaccination may prevent IS. We performed a systematic review and meta-analysis of available randomized clinical trials (RCTs) or prospective observational cohorts reporting associations of influenza vaccination (IV) and/or pneumococcal vaccination (PV) with IS. We identified a total of 12 studies (543,311 patients; 47.4% vaccinated). Vaccination was not related to the risk of IS (RR=1.06, 95%CI: 0.74 –1.51, p=0.77), with no significant differences (p=0.26) among RCTs (RR=0.66, 95%CI: 0.30–1.47) and observational studies (RR=1.11, 95%CI: 0.76–1.61).

Source: Journal of the Neurological Sciences - January 8, 2018 Category: Neurology Authors: Georgios Tsivgoulis, Aristeidis H. Katsanos, Ramin Zand, Muhammad Fawad Ishfaq, Muhammad Taimur Malik, Theodore Karapanayiotides, Konstantinos Voumvourakis, Sotirios Tsiodras, John Parissis Source Type: research