Covering the Cover

Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC), is the most common form of inherited colon cancer susceptibility. In most cases, it is characterized by mutations in the DNA mismatched repair genes, MSH2, MLH1, PMS1, MSH6, or MLH3. The Amsterdam criteria is a clinical guideline used to identify HNPCC in kindreds, and includes ≥3 relatives (one of whom is a first-degree relative and for whom familial adenomatous polyposis has been ruled out), HNPCC involving ≥2 generations, and ≥1 cancer that was diagnosed before the age of 50.

Source: Gastroenterology - August 21, 2014 Category: Gastroenterology Authors: Anson W. Lowe, Richard H. Moseley Tags: Covering the Cover Source Type: research