Human parainfluenza virus type 3 infections in hematopoietic stem cell transplantation patients: The mode of nosocomial infections and the prognosis.

Human parainfluenza virus type 3 infections in hematopoietic stem cell transplantation patients: The mode of nosocomial infections and the prognosis. Jpn J Infect Dis. 2017 Dec 26;: Authors: Kakiuchi S, Tsuji M, Nishimura H, Wang L, Takayama-Ito M, Kinoshita H, Lim CK, Taniguchi S, Oka A, Mizuguchi M, Saijo M Abstract   There have been few prospective and comprehensive surveillance studies on the respiratory viral infections (RVI) among patients undergoing hematopoietic stem cell transplantation (HSCT). A 2-year prospective cohort surveillance study of symptomatic and asymptomatic RVIs in hospitalized HSCT patients was performed. Oropharyngeal (OP) swab samples were serially collected each week from 1 week before and up to 100 days after HSCT and were tested for virus isolation with cell culture-based viral isolation (CC-based VI) and a multiplexed PCR (MPCR). 2,747 OP swab samples were collected from 250 HSCT patients (268 HSCT procedures) in total. Overall, 79 RVIs were detected (CC-based VI, n=63; MPCR, n=17). Parainfluenza virus type 3 (PIV3) accounted for 71% (57/80) of the RVIs. Some PIV3 infections were asymptomatic and involved a longer virus-shedding period. PIV3 was often cultured from samples taken before the onset of respiratory disease. The PIV3 infections were likely attributable to nosocomial transmission. PIV3 infections before engraftment were more likely to result in lower respiratory tract infections and a worse outcome. Moni...
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research

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AbstractWe performed a prospective study to evaluate the types and characteristics of central nervous system (CNS) disorders in patients after hematopoietic stem cell transplantation. The study included 163 episodes of CNS disorders of which 58 (36%) were infections. Proven or probable infections were documented in 34 patients and included fungi (n = 10, 29%), viruses (n = 12, 35%),Toxoplasma spp. (n = 9, 27%) and bacteria (n = 3, 9%). Non-infectious neurological disorders (n = 105, 64%) frequently encompassed metabolic/drug-induced abnormalities (n&thin...
Source: Journal of Neurology - Category: Neurology Source Type: research
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Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
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Source: Journal of B.U.ON. - Category: Cancer & Oncology Tags: J BUON Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
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Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
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Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
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Source: Bone Marrow Transplantation - Category: Hematology Authors: Source Type: research
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