Focused ultrasound-facilitated brain drug delivery using optimized nanodroplets: vaporization efficiency dictates large molecular delivery.

In conclusion, the vaporization efficiency of nanodroplets positively impacted the amount of molecules delivered to the brain. The OFP droplets due to the higher vaporization efficiency served as better acoustic agents to deliver large molecules safely and efficiently to the brain compared with the DFB droplets. PMID: 29260735 [PubMed - as supplied by publisher]
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research

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ConclusionsThe current rapid, multi-slice acquisition and real-time implementation of temperature and displacement visualization may be useful in clinical practices. It may help defining operational safety margins, improving therapy precision and efficacy. Simulations were in good agreement with experimental data and may thus be used prior treatment for procedure planning.
Source: NeuroImage - Category: Neuroscience Source Type: research
ConclusionsOur device represents an improvement and a valid alternative to the current methods diagnosing regional cerebral circulation.Graphical abstract
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
Conclusion: Considering the excellent diagnostic accuracy, ultrasonography can be used as an alternative means in diagnosis of metatarsal bone fractures. PMID: 31602432 [PubMed]
Source: Accident and Emergency Nursing - Category: Emergency Medicine Authors: Tags: Arch Acad Emerg Med Source Type: research
In this study, metal-organic framework-2 (MOF-2) nanomaterial (NM) was synthesized and then coupled with ultrasound (US) process in the presence of peroxydisulfate (S2O82−) for Acid Blue 7 (AB7) degradation as a triarylmethane model dye. The XRD, FT-IR, SEM, TEM, BET, and DRS analyses were utilized to confirm the appropriate formation of nanoporous flake-like MOF-2 with a high specific surface area of 942.6 m2/g. The combined US/MOF-2/S2O82− process demonstrated the highest performance compared to the US and US/S2O82− processes in the same operational conditions. The mentioned processes obeyed pseudo-fi...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Abstract The conventional Drug Delivery System (DDS) has limitations such as leakage of the drug, toxicity to normal cells and loss of drug efficiency, while the stimuli-responsive DDS is non-toxic to cells, avoiding the leakage and degradation of the drug because of its targeted drug delivery to the pathological site. Thus nanomaterial chemistry enables - the development of smart stimuli-responsive DDS over the conventional DDS. Stimuliresponsive DDS ensures spatial or temporal, on-demand drug delivery to the targeted cancer cells. The DDS is engineered by using the organic (synthetic polymers, liposomes, peptide...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
Publication date: Available online 13 October 2019Source: Seminars in Ultrasound, CT and MRIAuthor(s): Angelica Patino Gonzalez, Lucy Modahl, Daniel KowalAbstractImaging plays a central role in the diagnosis of pulmonary infections with the chest radiograph as the initial study of choice. CT can further delineate the extent of disease and present key imaging signs that, along with clinical history and laboratory data, can properly guide the differential diagnosis. In this article, we review and illustrate the most relevant CT imaging manifestations of common and less common pulmonary infections, including a section devoted...
Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
This article provides a foundation for evaluating deep neck infections through a review of essential anatomy and a discussion of important diseases that interact with these spaces.
Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
Publication date: Available online 12 October 2019Source: Seminars in Ultrasound, CT and MRIAuthor(s): D. Hynes, C. Duffin, T. CatanzanoAbstractHepatobiliary infections account for a small but clinically important proportion of emergency department presentations. They present a clinical challenge due to the broad range of imaging characteristics on presentation. Recognition of complications is imperative to drive appropriate patient care and resource utilisation to avoid diagnostic pitfalls and avert adverse patient outcomes. A thorough understanding of anatomy infectious pathology of hepatobiliary system is essential in t...
Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
Publication date: Available online 11 October 2019Source: Trends in Food Science &TechnologyAuthor(s): K.P. Thangavelu, J.P. Kerry, B. Tiwari, C.K. McDonnellAbstractBackgroundPhosphate additives are used in many processed foods as stabilisers and emulsifiers. They are present in up to 65% of processed meat products. However, consumer preferences for more natural and less processed foods has resulted in the growth of clean label trends, meaning shorter ingredient declarations using fewer ingredients that are unfamiliar to the consumer. Due to the unique characteristics of phosphates, their removal, while maintaining pro...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
Journal Name: Journal of Perinatal Medicine Issue: Ahead of print
Source: Journal of Perinatal Medicine - Category: Perinatology & Neonatology Source Type: research
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