Immune cell discovery could help to halt cancer spread

The critical importance of highly specialized immune cells, called natural killer cells, in killing melanoma cells that have spread to the lungs has been highlighted by new research. These natural killer cells could be harnessed to hunt down and kill cancers that have spread in the body, scientists report. The team also found natural killer cells were critical to the body's rejection of donor bone marrow transplants and in the runaway immune response during toxic shock syndrome.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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The objective of this compound is to decrease the rate of rectal toxicity related to radiation therapy, by creating a gap between the prostate and rectum. Secondary benefits include decreased urinary complications and improved sexual quality of life. The hydrogel spacer maintains space for approximately 3 months, and is absorbed in about 6 months.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 43: Follow Your Gut Source Type: research
To evaluate the efficacy and clinical impact of 3 Tesla in-bore trans-rectal magnetic resonance-guided biopsy (3T MRGB) for prostate cancer (PCa) detection based on PIRADSv2 in patients with either suspected prostate cancer or under active surveillance.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 43: Follow Your Gut Source Type: research
We describe our experience using MRI fused CBCT guidance for prostate biopsy. There are no published reports on the use of CBCT guidance in prostate biopsies. We hypothesize this technique will have an adequate safety profile while accurately detecting prostate cancer.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 39: Needle in a Haystack (Biopsies) Source Type: research
Image-guided thermal ablation has become the standard of care for treating early stage liver cancer. However, a significant limitation to a successful ablation procedure is the heat-sink effect, which may lead to suboptimal thermal dose delivery. Currently, there is no reliable method for quantifying the heat-sink effect due to limited information on blood vessel flow and its associated anatomy relative to the ablation zone. The purpose of this study was to use 4D-flow MRI to map out liver flow patterns and correlate flow rates with ablation zone volumes.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 38: All Kinds of Thermal Source Type: research
To evaluate safety and effectiveness of yttrium-90 radioembolization to treat hepatic metastases in uveal melanoma patients that also received adjuvant immunotherapy.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 34: Y-90 Y Not (Radioembolization II) Source Type: research
To report long-term outcomes of radioembolization (Y90) of hepatocellular carcinoma (HCC) patients within Milan Criteria and study success rate of bridging to liver transplantation (LT) vs drop-out rate from LT waitlist due to HCC progression.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 34: Y-90 Y Not (Radioembolization II) Source Type: research
Biphenotypic hepatocellular-cholangiocarcinoma (HCC-CC) is a rare type of primary liver cancer that carries a poor prognosis. Since most patients present at a stage too advanced for surgical resection, loco-regional liver directed therapy is often performed for palliative or downstaging purposes. The purpose of this study is to evaluate patient outcomes after Yttrium-90 radioembolization (Y90) in patients with HCC-CC.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 34: Y-90 Y Not (Radioembolization II) Source Type: research
Immunotherapy is a paradigm-shifting advance in cancer care, but the overall response rates remain low. There has been a renaissance in the concept of promoting the immune-responsiveness of the tumor immune microenvironment via intratumoral (IT) delivery of immunostimulatory agents. However, the optimal method for IT delivery of such medications that maximizes IT dispersion while minimizing perilesional leakage and systemic distribution is unknown. The purpose of this study was to characterize IT drug distribution and its influence on drug efficacy using conventional end-hole needles (EHNs) versus multi-sidehole needles (MSHN).
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 33: IO IO, It ’s Off to Work We Go Source Type: research
This study evaluates the relationship between onset of liver metastases and efficacy of LDT. It is our hypothesis that patients presenting with liver metastases soon after diagnosis of UM would have a worse prognosis regardless of LDT.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 33: IO IO, It ’s Off to Work We Go Source Type: research
Immunoembolization (IE) is an effective treatment for uveal melanoma (UM) hepatic metastases [1]. The purpose of this study is to determine the efficacy and safety of IE combined with systemic Ipilimumab (Ipi).
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 33: IO IO, It ’s Off to Work We Go Source Type: research
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