Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species

In conclusion, [Se-Se]-oxytocin-OH is a novel probe for validating OTR as a therapeutic target in various biological systems and is a promising new lead for therapeutic development. Our medicinal chemistry approach may also be applicable to other peptidergic signaling systems with similar selectivity issues.
Source: Signal Transduction Knowledge Environment - Category: Science Authors: Tags: STKE Research Resources Source Type: news

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This study was designed to test the hypothesis that induced maternal noninfectious fever alters neonatal neural progenitor cell proliferation and enhances microglial activation in the rat dentate gyrus of the hippocampus. METHODS: Systemic vehicle or IL-6 was given 3 times to near-term pregnant rats (n = 7/group) every 90 minutes, and maternal core temperature was recorded. Neonatal brains were processed and analyzed for dentate gyrus cell proliferation (using Ki-67, n = 10/group, and glial fibrillary acidic protein, n = 6/group) and resident microglia activation (using ionized calcium-binding adaptor protein-1 [Iba-1...
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
ConclusionsIN-associated AEs were identified among patients with UC, with liver dysfunction often being reversible, while surgical resection was required in a high proportion of patients who developed intussusception. Both healthcare workers and patients should adequately recognize the potential for AEs with the use of IN.
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research
ConclusionsChildren born early term are at increased risk of cognitive deficits, poorer school performance, and behavioral problems compared to children born full term.This article is protected by copyright. All rights reserved.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: Systematic review Source Type: research
Publication date: Available online 9 May 2019Source: Pharmacological ResearchAuthor(s): Shajila Siricilla, Kelsi M. Knapp, Jackson H. Rogers, Courtney Berger, Elaine L. Shelton, Dehui Mi, Paige Vinson, Jennifer Condon, Bibhash C. Paria, Jeff Reese, Quanhu Sheng, Jennifer L. HeringtonAbstractNovel therapeutic regulators of uterine contractility are needed to manage preterm labor, induce labor and control postpartum hemorrhage. Therefore, we previously developed a high-throughput assay for large-scale screening of small molecular compounds to regulate calcium-mobilization in primary mouse uterine myometrial cells. The goal o...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Despite women's preference for induction of labor (IOL) or dilation and evacuation (D&E) for pregnancy termination in the setting of second trimester fetal or pregnancy abnormality, many women are not given a choice between delivery methods. We investigated patient and clinical related factors associated with selecting IOL or D&E.
Source: Womens Health Issues - Category: Primary Care Authors: Tags: Original article Source Type: research
dsDNA breaks (DSBs) are resected in a 5′→3′ direction, generating single-stranded DNA (ssDNA). This promotes DNA repair by homologous recombination and also assembly of signaling complexes that activate the DNA damage checkpoint effector kinase Chk1. In fission yeast (Schizosaccharomyces pombe), genetic screens have previously uncovered a family of three xeroderma pigmentosum G (XPG)–related nucleases (XRNs), known as Ast1, Exo1, and Rad2. Collectively, these XRNs are recruited to a euchromatic DSB and are required for ssDNA production and end resection across the genome. Here, we studied why there a...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: DNA and Chromosomes Source Type: research
Condition:   Induction of Labor Affected Fetus / Newborn Intervention:   Diagnostic Test: Transvaginal sonography Sponsor:   Rambam Health Care Campus Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: The most cost-effective policy for detection and management of fetal macrosomia is selective ultrasound scanning coupled with induction of labour for all suspected cases of macrosomia. Universal ultrasound scanning for macrosomia in late-stage pregnancy is not cost-effective. This article is protected by copyright. All rights reserved. PMID: 31066982 [PubMed - as supplied by publisher]
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: BJOG Source Type: research
ConclusionsIOL in GDM mothers at term does not reduce CS rate and may be associated with increased CS rate among nulliparous women at 38  weeks. It is also associated with increased risk for adverse composite neonatal outcome or NICU admission when done prior to 390/7 weeks.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
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