Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species

In conclusion, [Se-Se]-oxytocin-OH is a novel probe for validating OTR as a therapeutic target in various biological systems and is a promising new lead for therapeutic development. Our medicinal chemistry approach may also be applicable to other peptidergic signaling systems with similar selectivity issues.

Source: Signal Transduction Knowledge Environment - December 5, 2017 Category: Science Authors: Muttenthaler, M., Andersson, A., Vetter, I., Menon, R., Busnelli, M., Ragnarsson, L., Bergmayr, C., Arrowsmith, S., Deuis, J. R., Chiu, H. S., Palpant, N. J., OBrien, M., Smith, T. J., Wray, S., Neumann, I. D., Gruber, C. W., Lewis, R. J., Alewood, P. F. Tags: STKE Research Resources Source Type: news