Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species

In conclusion, [Se-Se]-oxytocin-OH is a novel probe for validating OTR as a therapeutic target in various biological systems and is a promising new lead for therapeutic development. Our medicinal chemistry approach may also be applicable to other peptidergic signaling systems with similar selectivity issues.
Source: Signal Transduction Knowledge Environment - Category: Science Authors: Tags: STKE Research Resources Source Type: news

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CONCLUSIONS: Self-administration of misoprostol to induce pregnancy termination after 24 weeks' gestation contributes to preterm births and perinatal morbidity and mortality. The findings of this study show that there is a need to educate women on the perinatal and maternal risks associated with self-induced pregnancy termination at a late stage of gestation, availability of safe options for pregnancy termination, and contraceptive use and adherence. Healthcare workers need to be sensitive to the possibility that cases of apparent spontaneous preterm labour or birth may have been self-induced. PMID: 30645966 [PubMed - in process]
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
IntroductionStudies have shown that women with obesity have longer labors. The purpose of this systematic review and meta ‐analysis is to examine existing evidence regarding labor induction in women with obesity, including processes and outcomes. The primary outcome was cesarean birth following labor induction. Secondary outcomes were the timing and dosage of prostaglandins, the success of mechanical cervical ripenin g methods, and synthetic oxytocin dose and timing.MethodsSearches were performed in PubMed, MEDLINE, Embase, CINAHL, EBSCO, the Cochrane Database of Systematic Reviews, the Database of Abstracts of Effects, ...
Source: Journal of Midwifery and Women's Health - Category: Midwifery Authors: Tags: Review Source Type: research
eider MO Abstract Purpose Induction of labour for small-for-gestational-age (SGA) foetus or intrauterine growth restriction (IUGR) is common, but data are limited. The aim of this trial was therefore to compare labour induction for SGA/IUGR with cases with normal fetal growth beyond the 10th percentile. Material and methods This historical multicentre cohort study included singleton pregnancies at term. Labour induction for SGA/IUGR (IUGR group) was compared with cases of fetal growth beyond the 10th percentile (control group). Primary outcome measure was caesarean section rate. Results The caesarean section rate ...
Source: Zeitschrift fur Geburtshilfe und Neonatologie - Category: Perinatology & Neonatology Authors: Tags: Z Geburtshilfe Neonatol Source Type: research
Authors: Ożarowski M, Mikołajczak PŁ, Kujawski R, Wielgus K, Klejewski A, Wolski H, Seremak-Mrozikiewicz A Abstract Since improving maternal and child health is a public health priority worldwide, the main aim of treatment of hypertension in pregnant women is to prevent complications during pregnancy, labor, and postpartum. In consequence, much attention is paid to the use of antihypertensive drugs that can be used safely during pregnancy. Several side effects of methyldopa, which is currently the most commonly used antihypertensive drug in pregnant women, mean that the search for an effective and safe alternati...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Labor is induced in 20-30% of maternities with an increasing trend of use. Labor induction with oral misoprostol is associated with reduced risk of Cesarean births and has a comparable safety and effectiveness profile to mechanical method like with the Foley catheter. Labor induction in nulliparous women continues to be challenging with the process often quite protracted and eventual Cesarean rate is high and particularly so when the cervix is unfavorable and ripening is required. Vaginal examination can cause discomfort and emotional distress particularly to nulliparous women, so plausibly affect patient satisfaction with...
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Original Research: Obstetrics Source Type: research
Condition:   Induction of Labor Affected Fetus / Newborn Intervention:   Drug: Misoprostol Sponsor:   University of Maryland Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Among the various methods available, the administration of prostaglandins is the most effective for inducing labour in women with an unfavourable cervix. Recent studies have compared treatment with various tit...
Source: BMC Pregnancy and Childbirth - Category: OBGYN Authors: Tags: Study protocol Source Type: research
Amer J Perinatol DOI: 10.1055/s-0038-1676974 Objective To assess whether distraction using music and/or video games influences timing of analgesia request and improves pain outcomes in women undergoing labor induction. Study Design A total of 219 pregnant women with singleton gestation undergoing labor induction with a Foley bulb (FB) at term were randomized to distraction with music and video games via iPod (n = 109) or no iPod (n = 110). The primary outcome was the time from FB placement to request for pain medication. Secondary outcomes included number of patients requesting p...
Source: American Journal of Perinatology - Category: Perinatology & Neonatology Authors: Tags: Original Article Source Type: research
(Abstracted from BJOG 2018;125:1086–1095) It has been suggested that cervical ripening with a balloon catheter for labor induction can be done in an outpatient setting in low-risk pregnancies. Introduction of such an approach needs to be accompanied with monitoring of potential complications.
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: OBSTETRICS: MANAGEMENT OF LABOR, DELIVERY, AND THE PUERPERIUM Source Type: research
(Abstracted from N Engl J Med 2018;379:513–523) The perinatal and maternal consequences of induction of labor at 39 weeks among low-risk nulliparous women are uncertain. The ARRIVE trial (A Randomized Trial of Induction Versus Expectant Management) was designed to test the hypothesis that elective induction of labor at 39 weeks would result in a lower risk of a composite outcome of perinatal death or severe neonatal complications than expectant management among low-risk nulliparous women.
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: OBSTETRICS: MANAGEMENT OF LABOR, DELIVERY, AND THE PUERPERIUM Source Type: research
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