Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species

In conclusion, [Se-Se]-oxytocin-OH is a novel probe for validating OTR as a therapeutic target in various biological systems and is a promising new lead for therapeutic development. Our medicinal chemistry approach may also be applicable to other peptidergic signaling systems with similar selectivity issues.
Source: Signal Transduction Knowledge Environment - Category: Science Authors: Tags: STKE Research Resources Source Type: news

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Conditions:   Induced Labor;   Cervical Ripening;   Obstetric Labor;   Pregnancy Interventions:   Drug: Misoprostol 25 mcg;   Drug: Dinoprostone 10mg Sponsor:   Hospital Miguel Servet Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions that perinatal oxytocin increases the risks of neurodevelopmental problems are premature. Observational studies of low to high quality comprise the evidence-base, and confounding, especially by the genetic or environmental vulnerability, remains an issue. Current evidence is insufficient to justify modifying obstetric guidelines for the use of oxytocin, which state that it should only be used when clinically indicated. PMID: 30444210 [PubMed - as supplied by publisher]
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
Conditions:   Oxytocin;   Induction of Labor Intervention:   Drug: oxytocin Sponsor:   Zeynep Kamil Maternity and Pediatric Research and Training Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
For generations, midwives and doctors have looked for ways to imitate human physiology and nudge women’s bodies into giving birth. Synthetic hormones can be used to start and speed up labor. Soft balloons and seaweed sticks placed alongside the cervix can shape a pathway through the birth canal. Self-stimulation can spontaneously spark natural labor transmitters. But the start of labor remains a complex and mysterious process. And part of this mystery is figuring out which women to induce, when to induce labor, and how. Now, a landmark study known as ARRIVE has brought a bit of clarity. What does the study tell us ab...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Children's Health Family Planning and Pregnancy Health trends Women's Health Source Type: blogs
Conditions:   Oxytocin;   Induction of Labor Intervention:   Drug: oxytocin Sponsor:   Zeynep Kamil Maternity and Pediatric Research and Training Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionLow CPR, measured within 24 hours of induction of labor, is associated with increased risk of cesarean section for fetal distress and adverse neonatal outcome, but the performance of CPR for such surrogates of adverse perinatal outcome is poor.This article is protected by copyright. All rights reserved.
Source: Ultrasound in Obstetrics and Gynecology - Category: Radiology Authors: Tags: Original Paper Source Type: research
CONCLUSION: Low CPR, measured within 24 hours of induction of labor, is associated with increased risk of cesarean section for fetal distress and adverse neonatal outcome, but the performance of CPR for such surrogates of adverse perinatal outcome is poor. This article is protected by copyright. All rights reserved. PMID: 30426578 [PubMed - as supplied by publisher]
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
ConclusionLow CPR, measured within 24 hours of induction of labor, is associated with increased risk of cesarean section for fetal distress and adverse neonatal outcome, but the performance of CPR for such surrogates of adverse perinatal outcome is poor.This article is protected by copyright. All rights reserved.
Source: Ultrasound in Obstetrics and Gynecology - Category: Radiology Authors: Tags: Original Paper Source Type: research
Some economists want to make it more expensive for the less well-off to enjoy aclear revealed pleasure: eating red and processed meat.The  average household in the poorest fifth of the income distribution dedicates 1.3 percent of spending towards it. That’s over double average household spending in the richest quintile. Yet meat is now a new “public health” target. Once, lifestyle controls stopped at smoking and drinking. They recently expanded to soda and even caffeine. Now, even the hallowe d steak is not sacred.Last week,  a report by University of Oxford academics calculated suppos...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
This study's researchers approached all people turning 85 in 2006 in two cities in the UK for participation. At the beginning of the study in 2006-2007, there were 722 participants, 60 percent of whom were women. The participants provided researchers with information about what they ate every day, their body weight and height measurements, their overall health assessment (including any level of disability), and their medical records. The researchers learned that more than one-quarter (28 percent) of very old adults had protein intakes below the recommended dietary allowance. The researchers noted that older adults w...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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