In vivo Effects of Repeated Thyronamine Administration in Male C57BL/6J Mice

Conclusions: In summary, our data demonstrate that T0AM elicits no obvious metabolic, cardiovascular, or thermoregulatory activities in mice. As T0AM does also not interfere with TH or Se metabolism, we conclude that the deiodination of 3-T1AM to T0AM constitutes an efficient inactivation mechanism, terminating the actions of the more powerful precursor.Eur Thyroid J
Source: European Thyroid Journal - Category: Endocrinology Source Type: research