Role of Antiplatelet Therapy in Stroke Prevention in Patients With Atrial Fibrillation.

Role of Antiplatelet Therapy in Stroke Prevention in Patients With Atrial Fibrillation. J Am Osteopath Assoc. 2017 Dec 01;117(12):761-771 Authors: Manaktala R, Kluger J Abstract Patients with atrial fibrillation are at increased risk of having a cardioembolic stroke. The use of oral anticoagulation is now well established to prevent strokes in patients with atrial fibrillation and a CHA2DS2-VASc (congestive heart failure, hypertension, age ≥75 years [2 points], diabetes mellitus, prior stroke/transient ischemic attack or thromboembolism [2 points], vascular disease, age 65 to 74 years, and sex category) score of greater than 1, beyond sex. However, the role of antiplatelet therapy, specifically aspirin in low-risk patients or as an alternative to oral anticoagulation, remains controversial. The most recent US guidelines conflict with the European guidelines, which do not recommend antiplatelet monotherapy for stroke prevention irrespective of stroke risk. The aim of this review is to summarize published studies that question the role of aspirin in preventing strokes associated with atrial fibrillation. Overall, aspirin is found to play a limited role in the prevention of stroke in patients with atrial fibrillation and is associated with a similar risk of hemorrhagic events compared with anticoagulants. The benefit of dual antiplatelet therapy as an alternative to oral anticoagulation requires further study. PMID: 29181519 [PubMed - in process]
Source: Journal of the American Osteopathic Association - Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research

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CONCLUSIONS: This retrospective study further supports previous evidence that acellular fish skin graft promotes wound healing in DFUs. In particular, a rapid increase in wound healing was observed during the initial 4 weeks following graft application. This study and review of the literature indicated that fish graft encourages wound healing by enabling the wound to transition from a chronic to an acute stage of healing. PMID: 31730505 [PubMed - as supplied by publisher]
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
Learn all about how to detect type 1 diabetes in children and youth: signs, symptoms, and treatments.
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs
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Source: Diabetologia - Category: Endocrinology Source Type: research
Conclusions/interpretationShort-term structured strength and balance training did not influence HRQoL but produced sustained improvements in functional status and balance confidence at 6  months. More intensive interventions may be needed to influence HRQoL in these individuals. However, this intervention may be a useful treatment option for individuals with DPN to reduce the risk of falls and injuries.Trial registrationClinicalTrials.gov NCT02115932FundingThis work was supported by the National Medical Research Council, Singapore.
Source: Diabetologia - Category: Endocrinology Source Type: research
AbstractAims/hypothesisDiet is one of the main lifestyle-related factors that can modulate the inflammatory process. Surprisingly the dietary inflammatory index (DII) has been little investigated in relation to type 2 diabetes, and the role of BMI in this relationship is not well established. We studied this association and the role of BMI in the inflammatory process in a large population-based observational study.MethodsA total of 70,991 women from the E3N (Etude Epid émiologique auprès de femmes de la Mutuelle Générale de l’Education Nationale) cohort study were followed for 20 year...
Source: Diabetologia - Category: Endocrinology Source Type: research
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Source: Diabetologia - Category: Endocrinology Source Type: research
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Source: Diabetologia - Category: Endocrinology Source Type: research
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Source: Diabetologia - Category: Endocrinology Source Type: research
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Source: Diabetologia - Category: Endocrinology Source Type: research
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Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
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