Neonatal cardiomyocyte hypertrophy induced by endothelin-1 is blocked by estradiol acting on GPER.

In conclusion, E2 plays a key role in antagonizing ET-1-induced hypertrophy in cultured neonatal cardiomyocytes through GPER signaling by mechanism involving activation of PDK1 pathway, which would prevent the increase of ERK1/2 activity and consequently the development of hypertrophy. PMID: 29167148 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29167148?dopt=Abstract

Source: Am J Physiol Cell Ph... - November 22, 2017 Category: Cytology Authors: Goncalves GK, Scalzo S, Alves AP, Agero U, Guatimosim S, Reis AM Tags: Am J Physiol Cell Physiol Source Type: research