Patient and treatment factors associated with survival among pediatric glioblastoma patients: A Surveillance, Epidemiology, and End Results study

Publication date: Available online 6 November 2017 Source:Journal of Clinical Neuroscience Author(s): Sandi Lam, Yimo Lin, Pascal Zinn, Jack Su, I-Wen Pan Glioblastoma (GBM) is a rare malignancy in children. The United States Surveillance, Epidemiology, and End Results (SEER) database allows large-scale analyses of clinical characteristics and prognostic features. We used it to study patients aged <20 years with histologically confirmed GBM (2000–2010) and examined the relationship between patient demographics, tumor characteristics, patterns of treatment, and outcomes. The primary outcome was disease-specific survival. 302 subjects were identified, with median age 11 years. Median follow-up was 32 months (95% CI 27–39). 34.4% had gross total resection (GTR). 61% underwent radiation after surgery (17% of subjects <3 years, 67% of those aged 4–19 years). Median survival and 2-year survival rates were 20 months and 46.9%, respectively. In multivariate analyses, age, tumor location, extent of resection, and year of diagnosis were significantly associated with the primary outcome. Compared to those aged 0–4 years, subjects aged 5–9 years and 10–14 years had higher risk of mortality. Infratentorial tumor location (HR 2.0, 95% CI 1.2–3.3, p = 0.007) and subtotal resection (HR 2.04, 95% CI 1.4–3.0, p < 0.001) were associated with increased mortality. Later year of diagnosis was significantly associated with decrea...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research