Abstract B31: miRNAs regulated cancer metastasis in esophageal squamous cell carcinoma

MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs and negatively regulate gene expression through base pairing of 3' UTRs of the target genes. Over the past decade, much of important evidences have been obtained to clarify that miRNAs are unusual expressed in human malignancies and could act as OncomiRs or Tumor suppressive miRs.Esophageal squamous cell carcinoma (ESCC) is one of the most malignant cancers of the gastrointestinal tract. Especially, metastatic recurrences after esophagectomy for ESCC bears unfortunately prognosis and little exists for treatment strategy. Clarification of molecular indicators of the origin cellular deregulation in ESCC have been important objective for cancer research in ESCC.Recently, increasing number of studies have demonstrated the involvement of miRNAs in cancer metastasis. Especially, many studies have shown that microRNAs could target genes playing a role in epithelia-mesenchymal-transition (EMT), a cellular transformation process that allows cancer cells to acquire motility and invasiveness. EMT is considered an essential step driving the early phase of cancer metastasis.We search for miRNAs in ESCC using the miRNA expression signatures and gain-of-function analysis. It is revealed that 3 miRNAs (miR-145, miR-133a and miR-133b) inhibit cell proliferation and cell invasion. These miRNAs, which have conserved sequences in the 3' UTR of FSCN1, inhibited FSCN1 expression. The identification of tumor-suppressive miRNAs, miR-...
Source: Molecular Cancer Therapeutics - Category: Cancer & Oncology Authors: Tags: Other Topics: Oral Presentations - Proffered Abstracts Source Type: research