ATP-Evoked Sustained Vasoconstrictions Mediated by Heteromeric P2X1/4 Receptors in Cerebral Arteries [Basic Sciences]

Conclusions— This study reveals for the first time that apart from rapidly desensitizing homomeric P2X1Rs, heteromeric P2X1/4Rs contribute to the sustained component of the purinergic-mediated vasoconstriction in RMCA. Our study, therefore, identifies possible novel targets for therapeutical intervention in cerebral circulation.

http://stroke.ahajournals.org/cgi/content/short/45/8/2444?rss=1

Source: Stroke - July 28, 2014 Category: Neurology Authors: Harhun, M. I., Povstyan, O. V., Albert, A. P., Nichols, C. M. Tags: Cardiovascular Pharmacology, Cerebrovascular disease/stroke, Ion channels/membrane transport Basic Sciences Source Type: research