Lawsone derivatives target the Wnt/ β-catenin signaling pathway in multidrug-resistant acute lymphoblastic leukemia cells.

In conclusion, we found for the first time that the inhibition of Wnt/β-catenin signaling may represent a novel molecular mechanism of collateral sensitivity in MDR cells. Wnt/β-catenin signaling, therefore, represents a potential therapeutic target for the selective killing of Pgp-mediated MDR.
PMID: 29061340 [PubMed - as supplied by publisher]

Source: Biochemical Pharmacology - October 20, 2017 Category: Drugs & Pharmacology Authors: Hamdoun S, Fleischer E, Klinger A, Efferth T Tags: Biochem Pharmacol Source Type: research