Next-Generation Sequencing in Gynaecological Tumours: The Prognostic and Predictive Value of the Most Common Mutations Found in Ovarian, Endometrial, and Cervical Tumours: Literature Review and the University Medical Centre Utrecht Next-Generation Sequencing Data

Conclusion: In the ovaryKRAS mutation is associated with type I ovarian tumours (low-grade serous, mucinous, endometrioid, and clear-cell) and may seem to have a more favourable prognosis. The prognostic value ofTP53 is still controversial. In endometrial tumours,PTEN shows a positive correlation with better prognosis.PIK3CA may have a correlation with poorer prognosis.CTNNB1 mutations in endometrial carcinomas could predict a worse prognosis.Pathobiology
Source: Pathobiology - Category: Pathology Source Type: research