A microvascular compartment model validated using < sup > 11 < /sup > C-methylglucose liver PET in pigs.

A microvascular compartment model validated using <sup>11</sup>C-methylglucose liver PET in pigs. Phys Med Biol. 2017 Oct 18;: Authors: Munk OL, Keiding S, Baker C, Bass L Abstract The standard compartment model (CM) is widely used to analyze dynamic PET data. The CM is fitted to time-activity curves to estimate rate constants that describe the transport of tracer between well-mixed compartments. The aim of this study was to develop and validate a more realistic microvascular compartment model (MCM) that includes capillary tracer concentration gradients, backflux from cells into the perfused capillaries, and multiple re-uptakes during the passage through a capillary. &#13; The MCM incorporates only parameters with clear physiological meaning, it is easy to implement and it does not require numerical solution. We compared the MCM and CM for the analysis of 3-min dynamic PET data of pig livers (N=5) following injection of 11C-methylglucose. During PET scans, the tracer concentrations in blood were measured in the hepatic artery, portal vein, and liver vein by manual sampling. We found that the MCM outperformed the CM and that dynamic PET data include information, which cannot be extracted using standard CM. The MCM fitted dynamic PET data better than CM (Akaike values were 46 ± 4 for best MCM fits, and 82 ± 8 for best CM fits; mean ± standard deviation) and extracted physiologically reasonable parameter estimates suc...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research