Aquaporin ‐1 inhibition reduces metastatic formation in a mouse model of melanoma

In conclusion, these findings highlight an additional role for AQP1 as an important determinant of tumour dissemination by facilitating tumour cell extravasation and metastatic formation. This study adds knowledge on the role played by AQP1 in tumour biology and supports the view of AQP1 as a potential drug target for cancer therapy.

Source: Journal of Cellular and Molecular Medicine - October 1, 2017 Category: Molecular Biology Authors: Laura Simone, Concetta Domenica Gargano, Francesco Pisani, Antonio Cibelli, Maria Grazia Mola, Antonio Frigeri, Maria Svelto, Grazia Paola Nicchia Tags: Original Article Source Type: research