Hereditary diffuse gastric cancer and lynch syndromes in a BRCA1/2 negative breast cancer patient

DiscussionClinical manifestations, genetics, and management of both syndromes are reviewed, including prophylactic surgery and screening for unaffected family members. Management challenges for a mutation carrier with advanced breast cancer are discussed. Our case supports the clinical utility of additional multi-gene panel testing for breast cancer patients who do not have a pathogenic mutation in BRCA1/2 genes.

Source: Breast Cancer Research and Treatment - October 17, 2017 Category: Cancer & Oncology Source Type: research