Continued Alcohol Misuse in Human Cirrhosis is Associated with an Impaired Gut –Liver Axis

ConclusionsDespite cirrhosis, continued alcohol misuse predisposes patients to widespread dysbiosis with alterations in microbial functionality such as a toxic BA profile, which can lead to intestinal and systemic inflammation. In patients with cirrhosis who continue to misuse alcohol, there is evidence of greater endotoxemia and systemic inflammation stemming from widespread intestinal mucosal dysbiosis and microbial functionality. This is perpetuated by an altered enterohepatic cycling of bile acids and overproduction of secondary bile acids in the setting of ileal inflammation.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Facer.13498

Source: Alcoholism: Clinical and Experimental Research - October 11, 2017 Category: Addiction Authors: Jasmohan S. Bajaj, Genta Kakiyama, Derrick Zhao, Hajime Takei, Andrew Fagan, Phillip Hylemon, Huiping Zhou, William M. Pandak, Hiroshi Nittono, Oliver Fiehn, Nita Salzman, Mary Holtz, Pippa Simpson, Edith A. Gavis, Douglas M. Heuman, Runping Liu, Dae Joon Tags: Original article Source Type: research