Building a New Treatment for Ischemic Cardiomyopathy-Transplantation of Cell Sheet into the Failing Heart-

Background: Transplantation of autologous myoblast cells has been shown to yield functional recovery of the failing heart via paracrine effects. We have introduced skeletal myoblast cell (SMBc) sheet methods for treating severe heart failure (HF), in which scaffold-free cell-sheets are attached on the epicardial surface to maximize the paracrine effects. Aim: The aim of this study is to evaluate the mid-term outcome and therapeutic efficacy of SMBc sheet transplantation for treating severe HF due to ischemic cardiomyopathy.

Source: Journal of Cardiac Failure - September 20, 2017 Category: Cardiology Authors: Keitaro Domae, Shigeru Miyagawa, Kouichi Toda, Yasushi Yoshikawa, Hiroki Hata, Shunsuke Saito, Tetsuya Saito, Toru Kuratani, Takayoshi Ueno, Yoshiki Sawa Source Type: research