Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation.
Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation. J Immunol Res. 2017;2017:7807313 Authors: Lai CY, Su YW, Lin KI, Hsu LC, Chuang TH Abstract Psoriasis is a chronic inflammatory autoimmune disease that can be initiated by excessive activation of endosomal toll-like receptors (TLRs), particularly TLR7, TLR8, and TLR9. Therefore, inhibitors of endosomal TLR activation are being investigated for their ability to treat this disease. The currently approved biological drugs adalimumab, etanercept, infliximab, ustekinumab, ixekizumab, and secukizumab are antibodies against effector cytokines that participate in the initiation and development of psoriasis. Several immune modulatory oligonucleotides and small molecular weight compounds, including IMO-3100, IMO-8400, and CPG-52364, that block the interaction between endosomal TLRs and their ligands are under clinical investigation for their effectiveness in the treatment of psoriasis. In addition, several chemical compounds, including AS-2444697, PF-05387252, PF-05388169, PF-06650833, ML120B, and PHA-408, can inhibit TLR signaling. Although these compounds have demonstrated anti-inflammatory activity in animal models, their therapeutic potential for the treatment of psoriasis has not yet been tested. Recent studies demonstrated that natural compounds derived from plants, fungi, and bacteria, including mustard seed, Antrodia cinnamomea extract, curcumin, resveratrol, thiostrept...
CONCLUSION: The present work has confirmed the close relationship between vitiligo and psoriasis. PMID: 28919796 [PubMed]
AbstractPharmacogenetics is the study of variations in DNA sequence related to drug response. Moreover, the evolution of biotechnology and the sequencing of human DNA have allowed the creation of pharmacogenomics, a branch of genetics that analyzes human genes, the RNAs and proteins encoded by them, and the inter-and intra-individual variations in expression and function in relation to drug response. Pharmacogenetics and pharmacogenomics are being used to search for biomarkers that can predict response to systemic treatments, including those for moderate-to-severe psoriasis. Psoriasis is a chronic inflammatory disease with...
Conclusion: Our study showed that some IAD are not rare among PLHIV and occur mostly in patients with immuno-virological control under cART. The higher frequency of HCV or hepatitis B virus coinfection for some IAD is also confirmed.
DISCUSSION: Skin lesions due to acute MTX toxicity are rare, but they herald later-onset pancytopenia. Identification of these cutaneous lesions might enable earlier treatment initiation. The predilection of MTX toxicity for preexisting lesions or the de novo appearance of palmoplantar pustules should not lead to the erroneous diagnosis of psoriasis flare. PMID: 28917574 [PubMed - as supplied by publisher]
Publication date: Available online 9 September 2017 Source:Autoimmunity Reviews Author(s): Keum Hwa Lee, Andreas Kronbichler, David Duck-Young Park, YoungMin Park, Hanwool Moon, Hyungdo Kim, Jun Hyug Choi, YoungSeo Choi, Songjoo Shim, Il Suk Lyu, Byung Hwan Yun, Yeonseung Han, Donghee Lee, Sang Yoon Lee, Byung Hun Yoo, Kyung Hwan Lee, Tai Lim Kim, Heonki Kim, Joo Sung Shim, Wonseok Nam, Heesung So, SooYeon Choi, Sangmok Lee, Jae Il Shin The structures named neutrophil extracellular traps (NETs) are fibrous networks which protrude from the membrane of activated neutrophils. NETs are found in a variety of conditions, such a...
This study is set out to determine which subtype of the human ILC family is able to produce IL-17A. We found that stimulation of the unfractionated dermal ILC population with Candida albicans hyphae resulted in IL-17A production by type 3 ILC (ILC3).
Inflammatory autoimmune diseases like psoriasis and multiple sclerosis are characterized by the aberrant induction of interleukin (IL-) 12 and IL-23-producing type I dendritic cells (DC), resulting in pathogenic Th1/Th17 cell responses. We previously showed that the small molecule dimethyl fumarate (DMF) is able to improve inflammatory diseases by exerting potent immune modulatory activities. DMF treatment results in the generation of type II dendritic cells (DC) which then induce an anti-inflammatory Th2 response.
Interleukin 17-producing helper T cells (T(H)17 cells) play a role in protection against infections and have also been linked to autoimmune diseases like psoriasis. Th17 cells produce IL-17A/F, IL-22, and IL-26. Whereas the induction of IL-17 and IL-22 expression during Th17 differentiation has been well described, the mechanism regulating the production of IL-26 remains ill defined. Here, we found that IL-6 alone is required to generate IL-26-producing T cells from na ïve T cells but is not sufficient to induce IL-17 producing T cells.
Psoriasis is a long-lasting autoimmune disease. That consists of three parts, the first is abnormal keratinocyte differentiation, the second is hyperproliferation and the third is inflammatory elements influencing redness. Once pathogenic T cells have entered the skin, they become activated and release cytokines and chemokines to attract other immune cells to perpetuate the inflammatory cascade. Many kinds of chemokine “CXC” subfamily were expressed in psoriatic region. Keratinocytes play an important role in the regulation of skin immune response, responding to environmental stimuli.
Abstract Alopecia areata (AA) is a common autoimmune disease and it is challenging to predict which patients will have severe disease. The purpose of this retrospective study was to identify comorbidities in children enrolled in the National Alopecia Areata Registry. Atopic dermatitis was more common in patients with severe AA than in those with mild disease. The most common autoimmune comorbidities were vitiligo, psoriasis, thyroid disease, and juvenile idiopathic arthritis.