Effects of S 38093, an antagonist/inverse agonist of histamine H3 receptors, in models of neuropathic pain in rats

ConclusionsThese results highlight the interest of S 38093 to relieve neuropathic pain and warrant clinical trials especially in chemotherapeutic agent‐induced neuropathic pain.
SignificanceS 38093, a new H3 antagonist/inverse agonist, displays antiallodynic and antihyperalgesic effect in neuropathic pain, especially in oxaliplatin‐induced neuropathy after chronic administration. This effect of S 38093 in neuropathic pain could be partly mediated by α2 receptors desensitization in the locus coeruleus.

Source: European Journal of Pain - September 1, 2017 Category: Anesthesiology Authors: T. Chaumette, E. Chapuy, E. Berrocoso, M. Llorca ‐Torralba, L. Bravo, J.A. Mico, M. Chalus, A. Eschalier, D. Ardid, F. Marchand, A. Sors Tags: Original Article Source Type: research