Distinct Brain Metabolic Patterns Separately Associated with Cognition, Motor Function and Aging in Parkinson ’s Disease with Dementia

We explored whether patients with Parkinson ’s disease with dementia (PDD) show a distinct spatial metabolic pattern that characterizes cognitive deficits in addition to motor dysfunction. Eighteen patients with PDD underwent three separate positron emission tomography (PET) sessions with [18F]Fluorodeoxyglucose (FDG; for glucose metabolism ), Fluorinated N-3-fluoropropyl-2-beta-carboxymethoxy-3-beta-(4-iodophenyl) nortropane (FP-CIT; for dopamine transporter density) and Pittsburg Compound-B (PIB; for beta-amyloid load).

Source: Neurobiology of Aging - August 29, 2017 Category: Neuroscience Authors: Ji Hyun Ko, Audrey Katako, Maram Aljuaid, Andrew L. Goertzen, Andrew Borys, Douglas E. Hobson, Seok Min Kim, Chong Sik Lee, Alzheimer ’s Disease Neuroimaging Initiative Source Type: research